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Long-term effect of photodynamic therapy on oral squamous cell carcinoma and epithelial dysplasia
http://hdl.handle.net/10069/00041970
http://hdl.handle.net/10069/00041970c661ce99-9795-4ac2-b06a-9915dfc5e151
名前 / ファイル | ライセンス | アクション |
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PPT41_103246.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-01-17 | |||||
タイトル | ||||||
タイトル | Long-term effect of photodynamic therapy on oral squamous cell carcinoma and epithelial dysplasia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Photodynamic therapy (PDT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma (OSCC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epithelium dysplasia (ED) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Narahara, Shun
× Narahara, Shun× Ikeda, Hisazumi× Ogata, Kinuko× Shido, Rena× Asahina, Izumi× Ohba, Seigo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Oral squamous cell carcinoma (OSCC) treatment consists mainly of surgery, chemotherapy, and radiotherapy, alone or in combination. Epithelial dysplasia (ED) is also treated with surgery. However, these treatments can induce functional and/or aesthetic disturbances. Photodynamic therapy (PDT) can preserve organs. Although short-term studies have shown good progress, long-term evaluations have not yet been conducted. This study aimed to clarify the long-term effects of PDT on OSCC and ED. Methods: Patients who underwent PDT with the first (porfimer sodium) or second generation photosensitizers (talaporfin sodium) for early OSCC (T1 and T2) and ED were included in this study. The long-term prognosis was assessed. Results: Twenty-three patients were included. Complete response (CR) was observed in 19 patients (82.6%) and partial response (PR) in 4 patients (17.4%) 4 weeks after PDT. Regarding long-term progress, local region recurrence occurred in 11 of 19 CR cases (57.9%), and the term of recurrence was 27.4 ± 30.4 months. Surgical resection was performed in all local recurrence and PR cases, and 3 patients died of the underlying disease. Conclusions: PDT provides a good outcome in the short term, but its long-term effects are limited. |
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書誌情報 |
Photodiagnosis and Photodynamic Therapy 巻 41, p. 103246, 発行日 2022-12-16 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15721000 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.pdpdt.2022.103246 | |||||
権利 | ||||||
権利情報 | ⓒ 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Photodiagnosis and Photodynamic Therapy, 41, art. no. 103246; 2022 |