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Characteristics of azole-resistant Aspergillus fumigatus attached to agricultural products imported to Japan
http://hdl.handle.net/10069/00042032
http://hdl.handle.net/10069/0004203267936345-7fb9-4798-84d0-71aa93727e82
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2023-02-03 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Characteristics of azole-resistant Aspergillus fumigatus attached to agricultural products imported to Japan | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | Aspergillus fumigatus | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | Azole resistance | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | Agricultural imports | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | Japan | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
中野, 裕一郎
× 中野, 裕一郎
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著者別名 | ||||||||
姓名 | Nakano, Yuichiro | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Due to the increase in the number of azole-resistant Aspergillus fumigatus, there is an urgent need of data to predict future trends and prevent further spreading. The intercountry transfer of resistant A. fumigatus on plant bulbs have been reported. We investigated existence and characteristics of resistant isolates attached to agricultural products imported to Japan. We purchased 292 samples in Japan. All samples were screened for the existence of azole-resistant A. fumigatus. For positive isolates, minimum inhibitory concentrations of the drugs were determined. We also analyzed Cyp51A, Hmg1, and Erg6 mutations of these isolates and conducted microsatellite genotyping. Fourteen azole-resistant isolates were detected, of which 13 were cultured from flower bulbs imported from the Netherlands. Among them 5 were from 11 bulbs of Hippeastrum (45.5%), 5 were from 24 bulbs of Gladiolus (20.8%), 2 were from 4 bulbs of Ixia (50.0%), and 1 was from 22 bulbs of Tulipa (4.5%). Only 1 resistant isolate was cultured from the 10 bulbs of Narcissus (10.0%) originating in Japan. Various novel mutations including Y121F/T289A in Cyp51A with no tandem repeat in promoter region were discovered from imported strains. Our study provides important data showing that agricultural imports provide a possible route for their intercontinental spread and raises the concern that strains harboring highly diverse Cyp51A mutations might increase in clinical settings in the future. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1478号 学位授与年月日:令和4年12月7日 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: Yuichiro Nakano, Masato Tashiro, Ryo Urano, Minori Kikuchi, Naoki Ito, Eriko Moriya, Tomoyuki Shirahige, Maki Mishima, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Journal of Infection and Chemotherapy, 26(10), pp.1021-1025; 2020 | |||||||
書誌情報 |
Journal of Infection and Chemotherapy 巻 26, 号 10, p. 1021-1025, 発行日 2022-12-07 |
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ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1341-321X | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1016/j.jiac.2020.05.008 | |||||||
権利 | ||||||||
権利情報 | © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | 日本への輸入農産物に付着したアゾール耐性Aspergillus fumigatusの特徴について | |||||||
出版者 | ||||||||
出版者 | Elsevier Ltd. | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/00041985 | |||||||
学位名 | ||||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2022-12-07 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲医歯薬第1478号 | |||||||
学位の種類 | ||||||||
課程博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2022-12-07) |