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Severe esophagitis directly induced by accumulation of crizotinib-residue at the esophageal mucosa proven with polarizing microscope examination
http://hdl.handle.net/10069/00042161
http://hdl.handle.net/10069/00042161d794bef4-95c2-4501-b37b-8104394ae885
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ActMed66_99.pdf (539.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-30 | |||||
| タイトル | ||||||
| タイトル | Severe esophagitis directly induced by accumulation of crizotinib-residue at the esophageal mucosa proven with polarizing microscope examination | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Crizotinib | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | esophagitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ALK | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ROS-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polarizing microscopes | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Umeyama, Yasuhiro
× Umeyama, Yasuhiro× Taniguchi, Hirokazu× Yamaguchi, Hiroyuki× Shimada, Midori× Sugasaki, Nanae× Kinoshita, Akitoshi× Hayashi, Tomayoshi× Abe, Kuniko× Ono, Sawana× Gyotoku, Hiroshi× Senju, Hiroaki× Ikeda, Takaya× Nakatomi, Katsumi× Fukuda, Minoru× Takemoto, Shinnosuke× Mukae, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Crizotinib demonstrates dramatic effects for the patients with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase gene (ALK) fusion or c-ros oncogene 1 (ROS-1) fusion-positive lung cancer, with some characteristic toxicities. Although several studies reported that serious esophagitis was induced by crizotinib, the detailed mechanisms and ways to ameliorate the esophagitis have not been clarified. In this report, we report two cases with lung cancer who had been treated with crizotinib and developed severe esophagitis. Polarizing microscope examination clearly revealed that the accumulation of crizotinib-residue in the esophageal biopsy samples at the second anatomical narrowing of the esophagus in both cases. Since it seemed that the accumulation of crizotinib-residue in the esophageal mucosa directly caused the esophageal inflammation, we recommended taking crizotinib with a large amount of water (more than 200 ml) and to stay sitting upright for 30 minutes after intake. After that, the esophagitis gradually improved and the patients could continue taking crizotinib without dose reduction or withdrawal. Our experiences suggest that this crizotinib-induced esophagitis could be easily prevented by proper administration of crizotinib. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 66, 号 2, p. 99-103, 発行日 2023-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Nagasaki University School of Medicine | |||||
| 出版者別言語 | ||||||
| 値 | 長崎大学医学部 | |||||
| sortkey | ||||||
| 値 | 09 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia, 66(2), pp.99-103; 2023 | |||||
