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Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study
http://hdl.handle.net/10069/00042192
http://hdl.handle.net/10069/0004219229e86587-19eb-4bbb-a676-6dcaff904ed7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FI14_1124417.pdf (940.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-04-04 | |||||
| タイトル | ||||||
| タイトル | Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgG4-related disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | health checkup | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgG4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | magnetic bead panel assay | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | smoking | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsuji, Yoshika
× Tsuji, Yoshika× Koga, Tomohiro× Nonaka, Fumiaki× Nobusue, Kenichi× Kawashiri, Shin-ya× Yamanashi, Hirotomo× Maeda, Takahiro× Arima, Kazuhiko× Aoyagi, Kiyoshi× Takahashi, Meiko× Kawaguchi, Shuji× Matsuda, Fumihiko× Fujii, Hiroshi× Kawano, Mitsuhiro× Nakamura, Hiroyuki× Kawakami, Atsushi× Tamai, Mami |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: To allow the identification of IgG4-related disease (IgG4-RD) from a subclinical phase as it is important to understand the risk of elevated serum IgG4 levels. We planned to evaluate serum IgG4 levels in the participants of the Nagasaki Islands Study (NaIS), a large-scale health checkup cohort study. Methods: This study included 3,240 individuals who participated in the NaIS between 2016 and 2018 and consented to participate in the study. Serum IgG4, IgG, and IgE levels and human leukocyte antigen (HLA) genotyping results of the NaIS subjects as well as lifestyle habits and peripheral blood test results were analyzed. The magnetic bead panel assay (MBA) and the standard nephelometry immunoassay (NIA) were used to measure serum IgG4 levels. The data were evaluated using multivariate analysis to identify lifestyle and genetic factors associated with elevated serum IgG4 levels. Results: Serum IgG4 levels measured with the NIA and MBA showed a tight positive correlation between the two groups (correlation coefficient 0.942). The median age of the participants in the NaIS was 69 years [63–77]. The median serum IgG4 level was 30.2 mg/dL [IQR 12.5–59.8]. Overall, 1019 (32.1%) patients had a history of smoking. When the subjects were stratified into three groups based on the smoking intensity (pack-year), the serum IgG4 level was significantly higher among those with a higher smoking intensity. Accordingly, the multivariate analysis identified a significant relationship between smoking status and serum IgG4 elevation. Conclusion: In this study, smoking was identified as a lifestyle factor correlating positively with elevated serum IgG4 levels. |
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| 書誌情報 |
Frontiers in Immunology 巻 14, p. 1124417, 発行日 2023-03-08 |
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| 出版者 | ||||||
| 出版者 | Frontiers Media S.A. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1664-3224 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fimmu.2023.1124417 | |||||
| 権利 | ||||||
| 権利情報 | © 2023 Tsuji, Koga, Nonaka, Nobusue, Kawashiri, Yamanashi, Maeda, Arima, Aoyagi, Takahashi, Kawaguchi, Matsuda, Fujii, Kawano, Nakamura, Kawakami and Tamai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Frontiers in Immunology, 14, art. no. 1124417; 2023 | |||||
