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Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver
http://hdl.handle.net/10069/00042205
http://hdl.handle.net/10069/000422058db7ca6e-f663-4a9e-9a2e-fe501d30cef0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JRR64_228.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-04-10 | |||||
| タイトル | ||||||
| タイトル | Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | radiation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | low dose | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | low dose rate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | animal | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | epidemiology | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Suzuki, Keiji
× Suzuki, Keiji× Imaoka, Tatsuhiko× Tomita, Masanori× Sasatani, Megumi× Doi, Kazutaka× Tanaka, Satoshi× Kai, Michiaki× Yamada, Yutaka× Kakinuma, Shizuko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | While epidemiological data have greatly contributed to the estimation of the dose and dose-rate effectiveness factor (DDREF) for human populations, studies using animal models have made significant contributions to provide quantitative data with mechanistic insights. The current article aims at compiling the animal studies, specific to rodents, with reference to the dose-rate effects of cancer development. This review focuses specifically on the results that explain the biological mechanisms underlying dose-rate effects and their potential involvement in radiationinduced carcinogenic processes. Since the adverse outcome pathway (AOP) concept together with the key events holds promise for improving the estimation of radiation risk at low doses and low dose-rates, the review intends to scrutinize dose-rate dependency of the key events in animal models and to consider novel key events involved in the dose-rate effects, which enables identification of important underlying mechanisms for linking animal experimental and human epidemiological studies in a unified manner. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 64, 号 2, p. 228-249, 発行日 2023-02-11 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrad003 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2023. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of radiation research, 64(2), pp. 228-249; 2023 | |||||
