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Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report
http://hdl.handle.net/10069/38240
http://hdl.handle.net/10069/38240e8a7e88e-6074-4778-83fc-644f820e62a9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
OncLet15_7158.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-31 | |||||
| タイトル | ||||||
| タイトル | Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Brain metastasis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cetuximab resistance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Epidermal growth factor receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Epithelial-to-mesenchymal transition | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oral squamous cell carcinoma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Naruse, Tomofumi
× Naruse, Tomofumi× Tokuhisa, Mitsuko× Yanamoto, Souichi× Sakamoto, Yuki× Okuyama, Kohei× Tsuchihashi, Hiroki× Umeda, Masahiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment in a 60-year-old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N-cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial-to-mesenchymal transition potential. | |||||
| 書誌情報 |
Oncology Letters 巻 15, 号 5, p. 7158-7162, 発行日 2018-05 |
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| 出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17921074 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17921082 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/ol.2018.8261 | |||||
| 権利 | ||||||
| 権利情報 | c Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Oncology Letters, 15(5), pp.7158-7162; 2018 | |||||
