| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-10-11 |
| タイトル |
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タイトル |
IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Vasquez, Velasquez Clara
Russomando, Graciela
Espinola, Emilio E.
Sanchez, Zunilda
Mochizuki, Kota
Roca, Yelin
Revollo, Jimmy
Guzman, Angelica
Quiroga, Benjamin
Rios, Morgan Susana
Vargas, Ortiz Roberto
Zambrana, Ortega Alberto
Espinoza, Eida
Nishizawa, Juan Eiki
Kamel, Mohamed Gomaa
Kikuchi, Mihoko
Mizukami, Shusaku
Na-Bangchang, Kesara
Tien, Huy Nguyen
Hirayama, Kenji
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND: The National Program for Chagas disease was implemented in Bolivia in 2006, and it greatly decreased the number of infections through vector control. Subsequently, a treatment regimen of benznidazole (BNZ) was started in seropositive school-age children living in certified vector control areas. METHODS AND FINDINGS: We conducted a 12-month follow-up study and seven blood samples were taken during and after the treatment. Serology, conventional diagnostic PCR (cPCR) and quantitative Real-time PCR (qPCR) were performed. Plasma Th1/Th2/Th17 cytokines levels were also determined. Approximately 73 of 103 seropositive children complied with BNZ, with three interruptions due to side effects. To evaluate each individual's treatment efficacy, the cPCR and qPCR values during the final 6 months of the follow-up period were observed. Among 57 children who completed follow-up, 6 individuals (11%) showed both cPCR(+) and qPCR(+) (non reactive), 24 (42%) cPCR(-) but qPCR(+) (ambiguous) and 27 (47%) cPCR(-) and qPCR(-) (reactive). Within 14 Th1/Th2/Th17 cytokines, IL-17A showed significantly higher levels in seropositive children before the treatment compared to age-matched seronegative children and significantly decreased to the normal level one-year after. Moreover, throughout the follow-up study, IL-17A levels were positively co-related to parasite counts detected by qPCR. At the 12 months' time point, IL-17A levels of non-reactive subjects were significantly higher than either those of reactive or ambiguous subjects suggesting that IL-17A might be useful to determine the reactivity to BNZ treatment. CONCLUSIONS: Plasma levels of IL-17A might be a bio-marker for detecting persistent infection of T. cruzi and its chronic inflammation. |
| 書誌情報 |
PLOS Neglected Tropical Diseases
巻 13,
号 9,
p. e0007715,
発行日 2019-09-25
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| 出版者 |
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出版者 |
Public Library of Science |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19352735 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pntd.0007715 |
| 権利 |
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権利情報 |
c 2019 Va´squez Vela´squez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
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内容記述タイプ |
Other |
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内容記述 |
PLoS neglected tropical diseases, 13(9), e0007715; 2019 |
PLoSNeg13_0007715.pdf (2.5 MB)
