WEKO3
アイテム
A Combination Polymorphism of the Glutathione Synthesis Genes Can Be a Predictive Biomarker for Anti-Tuberculosis Drug-Induced Hepatotoxicity in Japanese Patients with Pulmonary Tuberculosis
http://hdl.handle.net/10069/36832
http://hdl.handle.net/10069/368327414d788-8a35-42c4-9058-f14d610c9285
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK887_Mawatari.pdf (954.6 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-13 | |||||
| タイトル | ||||||
| タイトル | A Combination Polymorphism of the Glutathione Synthesis Genes Can Be a Predictive Biomarker for Anti-Tuberculosis Drug-Induced Hepatotoxicity in Japanese Patients with Pulmonary Tuberculosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tuberculosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Anti-tuberculosis drug-induced hepatotoxicity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Single nucleotide polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glutathione synthesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Case-control association study | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
馬渡, 力
× 馬渡, 力 |
|||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115432 | |||||
| 姓名 | Mawatari, Tsutomu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: To identify certain genes related to anti-tuberculosis drug-induced hepatotoxicity (ATDH) for Japanese patients with pulmonary tuberculosis (TB), we examined an association study of single nucleotide polymorphisms (SNPs) in candidate genes in glutathione synthesis with susceptibility to ATDH. Method: We studied 100 TB patients treated with anti-TB drugs. The frequencies of alleles and genotypes of 17 tag SNPs in 3 genes between TB patients with and without ATDH were compared by chi-square test or Fisher's exact test in three different inheritance models. A genetic testing was carried out using a single or combination of the associated SNP(s) as a biomarker. Results: Statistical analyses indicated that a C/C genotype of rs553822 in glutamate cysteine ligase, catalytic subunit (GCLC) and an A/T or T/T genotype of rs12140446 in glutamate cysteine ligase, modifier subunit (GCLM) independently contributed to susceptibility to ATDH. Genetic testing showed that the TB patients without these polymorphisms of GCLC and GCLM could safely be treated with anti-TB drugs on the basis of the higher value for the specificity and negative predictive value. Conclusion: GCLC and GCLM are ATDH-related genes and may be useful as a new biomarker to predict the high-risk TB patients susceptible to ATDH. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第887号 学位授与年月日:平成28年9月7日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Mawatari T, Yoshida E, Higuchi N, Sato K, Inamine T, Kondo S, Fukushima K, Suyama N, Mukae H, Kohno S, Tsukamoto K | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Journal of Lung Diseases & Treatment, 2(2), 1000105; 2016 | |||||
| 書誌情報 |
Journal of Lung Diseases & Treatment 巻 2, 号 2, p. 1000105, 発行日 2016-09-07 |
|||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 24721018 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.4172/2472-1018.1000105 | |||||
| 権利 | ||||||
| 権利情報 | c 2016 Mawatari T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | グルタチオン合成関連遺伝子の多型の組み合わせは日本人肺結核患者における抗結核薬誘発性肝障害の予測バイオマーカーとなり得る | |||||
| 出版者 | ||||||
| 出版者 | OMICS International | |||||
| 学位名 | ||||||
| 学位名 | 博士(薬学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-09-07 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第887号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(薬学) (2016-09-07) | |||||
