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The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons
http://hdl.handle.net/10069/36843
http://hdl.handle.net/10069/36843e3694767-7f7a-4b1e-ba84-1abbe8bc30a8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK897_Baba.pdf (318.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-10-07 | |||||
| タイトル | ||||||
| タイトル | The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | myelodysplastic syndromes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | WT1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytopenia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IPSS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IPSS-R | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
馬場, 真紀
× 馬場, 真紀 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115442 | |||||
| 姓名 | Baba, Maki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Myelodysplastic syndromes (MDS) are a group of hematological neoplasms associated with ineffective hematopoiesis and that transform to acute leukemia. Distinguishing MDS from other cytopenias is sometimes difficult even for trained hematologists. WT1, the gene mutated in Wilms' tumor, was found expressed in acute myeloid leukemia and MDS. The amount of WT1 in peripheral blood and bone marrow (BM) is low in low-risk MDS subtypes, and is high in high-risk MDS subtypes. However, the role of WT1 in the differential diagnosis between MDS and other diseases showing cytopenia has not been fully addressed. The present study evaluated whether WT1 expression level can assist in the differential diagnosis of MDS from other cytopenias. Methods: The amount of WT1 message was evaluated among 56 MDS patients and 47 patients with cytopenia for various other reasons (cytopenia VR) at the Nagasaki University Hospital. Results: The level of WT1 was significantly related to the percentage of blasts in BM among MDS cases, and the type of French-American-British classification of MDS; refractory anemia (RA) cases showed significantly lower WT1 level than patients with RA with excess blasts. WT1 level was significantly related to the prognostic risk categories of MDS by the International Prognostic Scoring System (IPSS) and the revised IPSS. Although the blast percentage in the BM of RA and cytopenia VR were both less than 5%, there was a significant difference in the level of WT1 between MDS and cytopenia VR. Conclusion: WT1 might be a good marker to differentiate low blast percentage MDS and cytopenia VR. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第897号 学位授与年月日:平成28年10月5日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Maki Baba, Tomoko Hata, Hideki Tsushima, Sayaka Mori, Daisuke Sasaki, Kazuto Turuta, Hiroo Hasegawa, Koji Ando, Yasushi Sawayama, Daisuke Imanishi, Jun Taguchi, Katsunori Yanagihara, Masao Tomonaga, Shimeru Kamihira, Yasushi Miyazaki | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Internal Meicine, 54(5), pp.445-451; 2015 | |||||
| 書誌情報 |
Internal Medicine 巻 54, 号 5, p. 445-451, 発行日 2016-10-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09182918 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13497235 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2169/internalmedicine.54.3123 | |||||
| 権利 | ||||||
| 権利情報 | c 2015 by The Japanese Society of Internal Medicine | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 骨髄中のWT1発現量の測定は、芽球比率の低い骨髄異形成症候群とその他の理由による血球減少症との鑑別に有用である。 | |||||
| 出版者 | ||||||
| 出版者 | 日本内科学会 | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-10-05 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第897号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2016-10-05) | |||||
