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Drug fever after cancer chemotherapy is most commonly observed on posttreatment days 3 and 4
http://hdl.handle.net/10069/36937
http://hdl.handle.net/10069/369370991d84d-0e01-40c9-a942-ee4817ad550a
名前 / ファイル | ライセンス | アクション |
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SCC24_615.pdf (158.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-01 | |||||
タイトル | ||||||
タイトル | Drug fever after cancer chemotherapy is most commonly observed on posttreatment days 3 and 4 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug fever | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiotherapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ogawara, Daiki
× Ogawara, Daiki× Fukuda, Minoru× Ueno, Shiro× Ohue, Yoshihiro× Takemoto, Shinnosuke× Mizoguchi, Kosuke× Nakatomi, Katsumi× Nakamura, Yoichi× Obase, Yasushi× Honda, Takuya× Tsukamoto, Kazuhiro× Ashizawa, Kazuto× Oka, Mikio× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: This study was undertaken to analyze the characteristics of fever after cancer chemotherapy in order to reduce unnecessary medical care. Methods: Retrospectively, 1016 consecutive cycles of cancer chemotherapy were analyzed. Fever was defined as a temperature of ?37.5 °C lasting for 1 h. Age, sex, tumor histology, the treatment regimen, the timing of fever onset, the number of days for which the fever persisted, the cause of the fever, the presence or absence of radiotherapy, and the use of granulocyte colony-stimulating factor (G-CSF) were examined. Results: The patients included 748 males and 268 females (median age = 68, range = 29?88), of whom 949, 52, and 15 were suffering from lung cancer, malignant pleural mesothelioma, and other diseases, respectively. Fever was observed in 367 cycles (36 %), including 280 cycles (37 %) involving males and 87 cycles (32 %) involving females. Fever occurred most commonly in the first cycles and was higher than later cycles (41 vs. 30 %, p < 0.001). Fever occurred most frequently on posttreatment days 4 (8 %), 3 (7 %), and 12 (7 %), and the distribution of fever episodes exhibited two peaks on posttreatment days 3 and 4 and 10?14. Fever on posttreatment days 3 and 4 was most commonly observed in patients treated with gemcitabine (20 %) or docetaxel (18 %). The causes of fever included infection (47 %; including febrile neutropenia [24 %]), adverse drug effects (24 %), unknown causes (19 %), and tumors (7 %). Radiotherapy led to a significant increase in the frequency of fever (46 vs. 34 %, p < 0.001). Thirty-three percent of patients received G-CSF, and the incidence ratios of fever in patients who received G-CSF were higher than those who did not receive G-CSF (44 vs. 31 %, p < 0.001). Conclusion: The febrile episodes that occurred on posttreatment days 3 and 4 were considered to represent adverse drug reactions after cancer chemotherapy. Physicians should be aware of this feature of chemotherapy-associated fever and avoid unnecessary examination and treatments including prescribing antibiotics. |
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書誌情報 |
Supportive Care in Cancer 巻 24, 号 2, p. 615-619, 発行日 2016-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09414355 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14337339 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00520-015-2820-8 | |||||
権利 | ||||||
権利情報 | c Springer-Verlag Berlin Heidelberg 2015 | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Supportive Care in Cancer, 24(2), pp.615-619; 2016 |