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慢性疼痛を担う鍵分子リゾホスファチジン酸と脳を守る鍵分子プロサイモシンαに関する研究
http://hdl.handle.net/10069/39552
http://hdl.handle.net/10069/39552107b3fbb-b55b-4802-bc28-b9b34fec8b73
名前 / ファイル | ライセンス | アクション |
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Yakugaku139_1403.pdf (941.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-20 | |||||
タイトル | ||||||
タイトル | 慢性疼痛を担う鍵分子リゾホスファチジン酸と脳を守る鍵分子プロサイモシンαに関する研究 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kyotorphin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lysophosphatidic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prothymosin α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | opioid receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic pain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stroke | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
植田, 弘師
× 植田, 弘師 |
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著者別名 | ||||||
姓名 | Ueda, Hiroshi | |||||
その他のタイトル | ||||||
その他のタイトル | Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin α | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For my Ph.D. research topic, I isolated endogenous morphine-like analgesic dipeptide, kyotorphin, which mediates Met-enkephalin release, and discovered kyotorphin synthetase, a putative receptor and antagonist. Furthermore, I succeeded in purifying μ-opioid receptor and functional reconstitution with purified G proteins. After receiving my full professor position at Nagasaki University in 1996, I worked on two topics of research, molecular mechanisms of chronic pain through lysophosphatidic acid (LPA) and identification and characterization of neuroprotective protein, prothymosin α. In a series of studies, we have shown that LPA signaling defines the molecular mechanisms of neuropathic pain and fibromyalgia in terms of development and maintenance. Above all, the discovery of feed-forward system in LPA production and pain memory may contribute to better understanding of chronic pain and future analgesic drug discovery. Regarding prothymosin α, we first discovered it as neuronal necrosis-inhibitory molecule through two independent mechanisms, such as toll-like receptor and F0/F1 ATPase, both which protect neurons through indirect mechanisms. Prothymosin α is released by non-classical and non-vesicular mechanisms on various stresses, such as ischemia, starvation, and heat-shock. Thus it may be called a new type of neuroprotective damage-associated molecular patterns (DAMPs)/Alarmins. Heterozygotic mice showed a defect in memory-learning and neurogenesis as well as anxiogenic behaviors. Small peptide, P6Q derived from prothymosin α retains neuroprotective actions, which include blockade of cerebral hemorrhage caused by late treatment with tissue plasminogen activator in the stroke model in mice. | |||||
書誌情報 |
YAKUGAKU ZASSHI en : Journal of the Pharmaceutical Society of Japan 巻 139, 号 11, p. 1403-1415, 発行日 2019-11-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00316903 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475231 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/yakushi.19-00160 | |||||
権利 | ||||||
権利情報 | c 2019 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Yakugaku zasshi, 139(11), pp.1403-1415; 2019 |