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Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model
http://hdl.handle.net/10069/37099
http://hdl.handle.net/10069/370991174d40f-865d-43cf-a1a0-296d55b14934
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK923_Morishita.pdf (4.8 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-31 | |||||
| タイトル | ||||||
| タイトル | Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Foreign body giant cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteoclast | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hydroxyapatite | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Microstructure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cathepsin K | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
森下, 廣太
× 森下, 廣太 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115575 | |||||
| 姓名 | Morishita, Kota | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Foreign body giant cells (FBGCs) and osteoclasts are multinucleated giant cells (MNGCs), both of which are formed by the fusion of macrophage-derived mononuclear cells. Osteoclasts are distinct from FBGCs due to their bone resorption ability; however, not only morphological, but also functional similarities may exist between these cells. The characterization and diversity of FBGCs that appear in an in vivo foreign body reaction currently remain incomplete. In the present study, we investigated an in vivo foreign body reaction using an extraskeletal implantation model of hydroxyapatite (HA) with different microstructures. The implantation of HA granules in rat subcutaneous tissue induced a foreign body reaction that was accompanied by various MNGCs. HA granules composed of rod-shaped particles predominantly induced cathepsin K (CTSK)-positive FBGCs, whereas HA granules composed of globular-shaped particles predominantly induced CTSK-negative FBGCs. Plasma, which was used as the binder of ceramic granules, stimulated the induction of CTSK-positive FBGCs more strongly than purified fibrin. Furthermore, the implantation of HA composed of rod-shaped particles with plasma induced tartrate-resistant acid phosphatase (TRAP)-positive MNGCs in contrast to HA composed of globular-shaped particles with purified fibrin, which predominantly induced CTSK-negative and TRAP-negative typical FBGCs. These results suggest that CTSK-positive, TRAP-positive, and CTSK- and TRAP-negative MNGCs are induced in this subcutaneous implantation model in a manner that is dependent on the microstructure of HA and presence or absence of plasma. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第923号 学位授与年月日:平成29年3月21日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Kota Morishita, Eri Tatsukawa, Yasuaki Shibata, Fumio Suehiro, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku, Masahiro Umeda, Masahiro Nishimura, Tohru Ikeda | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Acta Biomaterialia, 39, pp.180-191; 2016 | |||||
| 書誌情報 |
Acta Biomaterialia 巻 39, p. 180-191, 発行日 2017-03-21 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17427061 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.actbio.2016.05.002 | |||||
| 権利 | ||||||
| 権利情報 | c 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 皮下移植実験系においてハイドロキシアパタイトの微細構造及び血漿成分の影響を受けて誘導される多様な多核巨細胞 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Ltd. | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-03-21 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第923号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2017-03-21) | |||||
