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γδ T Cell Immunotherapy?A Review
http://hdl.handle.net/10069/35161
http://hdl.handle.net/10069/35161660e2e70-958b-45bf-9a93-36fab073421c
名前 / ファイル | ライセンス | アクション |
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Pharma8_40.pdf (796.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-31 | |||||
タイトル | ||||||
タイトル | γδ T Cell Immunotherapy?A Review | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer immunotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nitrogen-containing bisphosphonate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphoantigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vγ9Vδ2 T cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kobayashi, Hirohito
× Kobayashi, Hirohito× Tanaka, Yoshimasa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cancer immunotherapy utilizing Vγ9Vδ2 T cells has been developed over the past decade. A large number of clinical trials have been conducted on various types of solid tumors as well as hematological malignancies. Vγ9Vδ2 T cell-based immunotherapy can be classified into two categories based on the methods of activation and expansion of these cells. Although the in vivo expansion of Vγ9Vδ2 T cells by phosphoantigens or nitrogen-containing bisphosphonates (N-bis) has been translated to early-phase clinical trials, in which the safety of the treatment was confirmed, problems such as activation-induced Vγ9Vδ2 T cell anergy and a decrease in the number of peripheral blood Vγ9Vδ2 T cells after infusion of these stimulants have not yet been solved. In addition, it is difficult to ex vivo expand Vγ9Vδ2 T cells from advanced cancer patients with decreased initial numbers of peripheral blood Vγ9Vδ2 T cells. In this article, we review the clinical studies and reports targeting Vγ9Vδ2 T cells and discuss the development and improvement of Vγ9Vδ2 T cell-based cancer immunotherapy. | |||||
書誌情報 |
Pharmaceuticals 巻 8, 号 1, p. 40-61, 発行日 2015-02-12 |
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出版者 | ||||||
出版者 | Multidisciplinary Digital Publishing Institute (MDPI) | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14248247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ph8010040 | |||||
権利 | ||||||
権利情報 | c 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pharmaceuticals, 8(1), pp.40-61; 2015 |