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Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice
http://hdl.handle.net/10069/35169
http://hdl.handle.net/10069/35169a7975632-ccc3-4f83-b7b9-febb9574ed77
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SciRep5_8055.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-03-31 | |||||
| タイトル | ||||||
| タイトル | Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Guo, Chang-Ying
× Guo, Chang-Ying× Luo, Lan× Urata, Yoshishige× Goto, Shinji× Huang, Wen-Jing× Takamura, Syu× Hayashi, Fumiko× Doi, Hanako× Kitajima, Yuriko× Ono, Yusuke× Ogi, Tomoo× Li, Tao-Sheng |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We evaluated the sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells. Adult C57BL/6 mice were daily exposed to 0, 2, 10, 50, and 250 mGy γ-ray for 1 month in succession, respectively. The damage of hematopoietic stem/progenitor cells in bone marrow were investigated within 2 hours (acute phase) or at 3 months (chronic phase) after the last exposure. Daily exposure to over 10 mGy γ-ray significantly decreased the number and colony-forming capacity of hematopoietic stem/progenitor cells at acute phase, and did not completely recover at chronic phase with 250 mGy exposure. Interestingly, the daily exposure to 10 or 50 mGy γ-ray decreased the formation of mixed types of colonies at chronic phase, but the total number of colonies was comparable to control. Immunostaining analysis showed that the formation of 53BP1 foci in c-kit + stem/progenitor cells was significantly increased with daily exposure to 50 and 250 mGy at acute phase, and 250 mGy at chronic phase. Many genes involved in toxicity responses were up- or down-regulated with the exposures to all doses. Our data have clearly shown the sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells of mice with daily exposures to 2 ? 250 mGy γ-ray. | |||||
| 書誌情報 |
Scientific Reports 巻 5, p. 8055, 発行日 2015-01-27 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep08055 | |||||
| 権利 | ||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Scientific Reports, 5, 8055; 2015 | |||||
