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Modest Attenuation of HIV-1 Vpu Alleles Derived from Elite Controller Plasma
http://hdl.handle.net/10069/35304
http://hdl.handle.net/10069/353044466c23f-6df9-42c0-94f0-3d61aa7e94f4
名前 / ファイル | ライセンス | アクション |
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PLoS10_120434.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-12 | |||||
タイトル | ||||||
タイトル | Modest Attenuation of HIV-1 Vpu Alleles Derived from Elite Controller Plasma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chen, Jingyan
× Chen, Jingyan× Tibroni, Nadine× Sauter, Daniel× Galaski, Johanna× Miura, Toshiyuki× Alter, Galit× Mueller, Birthe× Haller, Claudia× Walker, Bruce D.× Kirchhoff, Frank× Brumme, Zabrina L.× Ueno, Takamasa× Fackler, Oliver T. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the absence of antiretroviral therapy, infection with human immunodeficiency virus type 1 (HIV-1) can typically not be controlled by the infected host and results in the development of acquired immunodeficiency. In rare cases, however, patients spontaneously control HIV-1 replication. Mechanisms by which such elite controllers (ECs) achieve control of HIV-1 replication include particularly efficient immune responses as well as reduced fitness of the specific virus strains. To address whether polymorphisms in the accessory HIV-1 protein Vpu are associated with EC status we functionally analyzed a panel of plasma-derived vpu alleles from 15 EC and 16 chronic progressor (CP) patients. Antagonism of the HIV particle release restriction by the intrinsic immunity factor CD317/tetherin was well conserved among EC and CP Vpu alleles, underscoring the selective advantage of this Vpu function in HIV-1 infected individuals. In contrast, interference with CD317/tetherin induced NF-eκB activation was little conserved in both groups. EC Vpus more frequently displayed reduced ability to downregulate cell surface levels of CD4 and MHC class I (MHC-I) molecules as well as of the NK cell ligand NTB-A. Polymorphisms potentially associated with high affinity interactions of the inhibitory killer immunoglobulin-like receptor (KIR) KIR2DL2 were significantly enriched among EC Vpus but did not account for these functional differences. Together these results suggest that in a subgroup of EC patients, some Vpu functions are modestly reduced, possibly as a result of host selection. | |||||
書誌情報 |
PLOS ONE 巻 10, 号 3, p. e0120434, 発行日 2015-03-20 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0120434 | |||||
権利 | ||||||
権利情報 | c 2015 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLOS ONE, 10(3), e0120434; 2015 |