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Characteristic patterns of relapse after allogeneic hematopoietic SCT for adult T-cell leukemia?lymphoma: a comparative study of recurrent lesions after transplantation and chemotherapy by the Nagasaki Transplant Group
http://hdl.handle.net/10069/35605
http://hdl.handle.net/10069/3560555d06d56-a528-4d05-bdfc-99e32f071a79
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Supple.pdf (127.1 kB)
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BMT50_585.pdf (510.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-10-05 | |||||
タイトル | ||||||
タイトル | Characteristic patterns of relapse after allogeneic hematopoietic SCT for adult T-cell leukemia?lymphoma: a comparative study of recurrent lesions after transplantation and chemotherapy by the Nagasaki Transplant Group | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult T-cell leukemia-lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | relapse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor lesion | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Itonaga, Hidehiro
× Itonaga, Hidehiro× Sawayama, Yasushi× Taguchi, Jun× Honda, Sumihisa× Taniguchi, Hiroaki× Makiyama, Junnya× Matsuo, Emi× Sato, Shinya× Ando, Koji× Imanishi, Daisuke× Imaizumi, Yoshitaka× Yoshida, Shinichiro× Hata, Tomoko× Moriuchi, Yukiyoshi× Fukushima, Takuya× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Allogeneic hematopoietic SCT (allo-SCT) is a promising therapy that may provide long-term durable remission for adult T-cell leukemia-lymphoma (ATL) patients; however, the incidence of relapse associated with ATL remains high. To determine the clinical features of these patients at relapse, we retrospectively analyzed tumor lesions in 30 or 49 patients who relapsed following allo-SCT or chemotherapy (CHT), respectively, at three institutions in Nagasaki prefecture between 1997 and 2011. A multivariate analysis revealed that the development of abnormal lymphocytes in the peripheral blood of patients at relapse was less frequent after allo-SCT than after CHT (P<0.001). Furthermore, relapse with a new lesion only in the absence of the primary lesion was more frequent in allo-SCT (P=0.014). Lesions were more frequently observed in the central nervous systems of patients who relapsed with new lesions only (P=0.005). Thus, the clinical manifestation of relapsed ATL was slightly complex, especially in post-transplant patients. Our results emphasized the need to develop adoptive modalities for early and accurate diagnoses of relapsed ATL. | |||||
書誌情報 |
Bone Marrow Transplantation 巻 50, 号 4, p. 585-591, 発行日 2015-04-04 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02683369 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14765365 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/bmt.2014.308 | |||||
権利 | ||||||
権利情報 | c 2015 Macmillan Publishers Limited. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone Marrow Transplantation, 50(4), pp.585-591; 2015 |