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Castalagin Exerts Inhibitory Effects on Osteoclastogenesis Through Blocking a Broad Range of Signaling Pathways with Low Cytotoxicity
http://hdl.handle.net/10069/35624
http://hdl.handle.net/10069/35624304fe5d3-bf92-4b2c-a419-0b7f3f1d642a
名前 / ファイル | ライセンス | アクション |
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PhyRes29_917.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-07-01 | |||||
タイトル | ||||||
タイトル | Castalagin Exerts Inhibitory Effects on Osteoclastogenesis Through Blocking a Broad Range of Signaling Pathways with Low Cytotoxicity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | castalagin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NFATc1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Iwatake, Mayumi
× Iwatake, Mayumi× Okamoto, Kuniaki× Tanaka, Takashi× Tsukuba, Takayuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Castalagin is a rare plant polyphenol that is classified as a hydrolyzable tannin. Although it has antioxidant, antitumorigenic, and leishmanicidal effects, the utility of castalagin against bone diseases remain to be elucidated. Here, we investigated the effects of castalagin on the differentiation of osteoclasts (OCLs), multinucleated bone-resorbing cells. After stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL), the formation of OCLs from bone marrow-derived macrophages was significantly inhibited by castalagin even at 1-μM. However, castalagin displayed little cytotoxicity at a higher concentration of 50-μM. The effects of castalagin on intracellular signaling during OCL differentiation showed that castalagin suppresses RANKL-stimulated phosphorylation of major signaling pathways including protein kinase B (Akt), extracellular signal-regulated kinase, Jun N-terminal kinase, p38 mitogen-activated protein kinases, and inhibitor of nuclear factor kappa B alpha. Moreover, following castalagin treatment, the protein levels of nuclear factor of activated T-cells, cytoplasmic 1, a master regulator for OCL differentiation, and NF-κB were decreased. Thus, castalagin exerts inhibitory effects on osteoclastogenesis through blockage of a broad range of signaling pathways, but has low cytotoxicity. | |||||
書誌情報 |
Phytotherapy Research 巻 29, 号 6, p. 917-924, 発行日 2015-06 |
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出版者 | ||||||
出版者 | John Wiley and Sons Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0951418X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/ptr.5333 | |||||
権利 | ||||||
権利情報 | c 2015 John Wiley & Sons, Ltd. | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Phytotherapy Research, 29(6), pp.917-924; 2015, which has been published in final form at http://dx.doi.org/10.1002/ptr.5333 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Phytotherapy Research, 29(6), pp.917-924; 2015 |