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深在性真菌症患者におけるLiposomal Amphotericin B(L-AMB)の薬物動態および安全性の検討
http://hdl.handle.net/10069/34113
http://hdl.handle.net/10069/34113800c33e1-d017-4f1f-aee7-63a784e2a13a
名前 / ファイル | ライセンス | アクション |
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JJC61_369.pdf (688.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-02-07 | |||||
タイトル | ||||||
タイトル | 深在性真菌症患者におけるLiposomal Amphotericin B(L-AMB)の薬物動態および安全性の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Deep-seated fungal infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liposomal amphotericin B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
河野, 茂
× 河野, 茂× 小林, 宏行× 正岡, 徹× 浦部, 晶夫× 金丸, 昭久× 二木, 芳人× 森, 健× 原, 耕平× 池本, 秀雄× 馬庭, 貴司× 中條, 英司× 鈴木, 孝太× 山口, 英世 |
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著者別名 | ||||||
姓名 | Kohno, Shigeru | |||||
著者別名 | ||||||
姓名 | Kobayashi, Hiroyuki | |||||
著者別名 | ||||||
姓名 | Masaoka, Toru | |||||
著者別名 | ||||||
姓名 | Urabe, Akio | |||||
著者別名 | ||||||
姓名 | Kanamaru, Akihisa | |||||
著者別名 | ||||||
姓名 | Niki, Yoshihito | |||||
著者別名 | ||||||
姓名 | Mori, Takeshi | |||||
著者別名 | ||||||
姓名 | Hara, Kohei | |||||
著者別名 | ||||||
姓名 | Ikemoto, Hideo | |||||
著者別名 | ||||||
姓名 | Maniwa, Takashi | |||||
著者別名 | ||||||
姓名 | Nakajo, Eiji | |||||
著者別名 | ||||||
姓名 | Suzuki, Kota | |||||
著者別名 | ||||||
姓名 | Yamaguchi, Hideyo | |||||
その他のタイトル | ||||||
その他のタイトル | Evaluation of pharmacokinetics and safety of liposomal amphotericin B (L-AMB) in patients with deep-seated fungal infection | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 深在性真菌症罹患患者32名(23~73歳)を対象にLiposomal amphotericin B(L-AMB)を1.0 mg/kg/日,2.5 mg/kg/日または5.0 mg/kg/日の用量で原則7日間連日点滴静注し,薬物動態と安全性を検討した。L-AMB投与1日目の薬物動態ではCmax(平均値±標準偏差)は1.0 mg/kg/日,2.5 mg/kg/日,5.0 mg/kg/日の各用量でそれぞれ5.96±3.02 μg/mL,16.19±7.41 μg/mL,45.71±20.14 μg/mL,また,AUC0-24(平均値±標準偏差)では55.5±39.0 μg・hr/mL,138.5±56.5 μg・hr/mL,390.3±223.2 μg・hr/mLと用量が増すにつれ増加したが,投与量に対し非線形的な相関を示した。副作用は,用量が増すにつれ種類,頻度が増加する傾向にあった。1.0 mg/kg/日投与群で14例中10例(71.4%),2.5 mg/kg/日投与群で9例中8例(88.9%),5.0 mg/kg/日投与群で9例中9例(100%)であった。しかし,本剤の投与を制限する重篤な副作用は認められず,1.0 mg/kg/日~5.0 mg/kg/日を連日投与した場合の安全性と忍容性が確認された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The pharmacokinetics and safety of liposomal amphotericin B (L-AMB) were evaluated in 32 patients with deep-seated fungal infections (age, 23-73 years) after intravenous infusion at a dose of 1.0, 2.5, or 5.0 mg/kg/day for seven consecutive days. On Day 1 of treatment with L-AMB at doses of 1.0, 2.5, and 5.0 mg/kg/day, the Cmax (mean ± standard deviation [SD]) was 5.96 ± 3.02, 16.19 ± 7.41, and 45.71 ± 20.14 μg/mL, respectively, and the AUC0-24 (mean ± SD) was 55.5 ± 39.0, 138.5 ± 56.5, and 390.3 ± 223.2 μg・hr/mL, respectively. The Cmax and AUC0-24 increased with increasing doses, but not in a linear manner. The type and incidence of adverse drug reactions tended to increase with increasing doses. Adverse drug reactions were reported in 10 (71.4%) of the 14 subjects in the 1.0-mg/kg/day group, 8 (88.9%) of the 9 subjects in the 2.5-mg/kg/day group, and all (100%) of the 9 subjects in the 5.0-mg/kg/day group. However, no serious, dose-limiting adverse drug reactions occurred, demonstrating the safety and tolerability of daily treatment with L-AMB at doses of 1.0 to 5.0 mg/kg/day. | |||||
書誌情報 |
日本化学療法学会雑誌 en : Japanese Journal of Chemotherapy 巻 61, 号 4, p. 369-379, 発行日 2013-07 |
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出版者 | ||||||
出版者 | 日本化学療法学会 | |||||
出版者別言語 | ||||||
Japan Society of Chemotherapy | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13407007 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10472127 | |||||
権利 | ||||||
権利情報 | c 日本化学療法学会 All rights reserved. | |||||
権利 | ||||||
権利情報 | 利用は著作権の範囲内に限られる。 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本化学療法学会雑誌, 61(4), pp.369-379, 2013 |