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  1. 110 医歯薬学総合研究科 = Graduate School of Biomedical Sciences
  2. 110 学術雑誌論文 = Articles in academic journal

STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

http://hdl.handle.net/10069/34392
http://hdl.handle.net/10069/34392
55d837bb-ad22-4b4c-821b-b8491d98933a
名前 / ファイル ライセンス アクション
DisMar2014_727393.pdf DisMar2014_727393.pdf (174.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-05-16
タイトル
タイトル STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Joshita, Satoru

× Joshita, Satoru

WEKO 22426

Joshita, Satoru

Search repository
Umemura, Takeji

× Umemura, Takeji

WEKO 22427

Umemura, Takeji

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Nakamura, Minoru

× Nakamura, Minoru

WEKO 22428

Nakamura, Minoru

Search repository
Katsuyama, Yoshihiko

× Katsuyama, Yoshihiko

WEKO 22429

Katsuyama, Yoshihiko

Search repository
Shibata, Soichiro

× Shibata, Soichiro

WEKO 22430

Shibata, Soichiro

Search repository
Kimura, Takefumi

× Kimura, Takefumi

WEKO 22431

Kimura, Takefumi

Search repository
Morita, Susumu

× Morita, Susumu

WEKO 22432

Morita, Susumu

Search repository
Komatsu, Michiharu

× Komatsu, Michiharu

WEKO 22433

Komatsu, Michiharu

Search repository
Matsumoto, Akihiro

× Matsumoto, Akihiro

WEKO 22434

Matsumoto, Akihiro

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Yoshizawa, Kaname

× Yoshizawa, Kaname

WEKO 22435

Yoshizawa, Kaname

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Ishibashi, Hiromi

× Ishibashi, Hiromi

WEKO 22436

Ishibashi, Hiromi

Search repository
Tanaka, Eiji

× Tanaka, Eiji

WEKO 22437

Tanaka, Eiji

Search repository
Ota, Masao

× Ota, Masao

WEKO 22438

Ota, Masao

Search repository
抄録
内容記述タイプ Abstract
内容記述 susceptibility. Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. Single nucleotide polymorphisms (SNPs) were genotyped in 395 PBC patients and 458 healthy subjects of Japanese ethnicity and evaluated for associations with PBC susceptibility, anti-nuclear antibody (ANA) status, and anti-mitochondrial antibody (AMA) status. We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P = 9.4 × 10 - 3, rs11889341; P = 1.2 × 10 - 3, rs7574865; P = 4.0 × 10 - 4, rs8179673; P = 2.0 × 10 - 4, and rs10181656; P = 4.2 × 10 - 5). Three risk alleles (rs7574865; P = 0.040, rs8179673; P = 0.032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.
書誌情報 Disease Markers

巻 2014, p. 1-8, 発行日 2014
出版者
出版者 Hindawi Publishing Corporation
ISSN
収録物識別子タイプ ISSN
収録物識別子 02780240
EISSN
収録物識別子タイプ ISSN
収録物識別子 18758630
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1155/2014/727393
権利
権利情報 c 2014 Satoru Joshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
引用
内容記述タイプ Other
内容記述 Disease Markers, 2014, 27393; 2014
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