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Involvement of the Wbp pathway in the biosynthesis of Porphyromonas gingivalis lipopolysaccharide with anionic polysaccharide
http://hdl.handle.net/10069/34514
http://hdl.handle.net/10069/3451405e1512a-e51c-4589-b8ec-348d5791c726
| 名前 / ファイル | ライセンス | アクション |
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SciRep4_5056.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2014-06-27 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Involvement of the Wbp pathway in the biosynthesis of Porphyromonas gingivalis lipopolysaccharide with anionic polysaccharide | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Shoji, Mikio
× Shoji, Mikio
× Sato, Keiko
× Yukitake, Hideharu
× Naito, Mariko
× Nakayama, Koji
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The periodontal pathogen Porphyromonas gingivalis has two different lipopolysaccharide (LPS) molecules, O-LPS and A-LPS. We have recently shown that P. gingivalis strain HG66 lacks A-LPS. Here, we found that introduction of a wild-type wbpB gene into strain HG66 restored formation of A-LPS. Sequencing of the wbpB gene from strain HG66 revealed the presence of a nonsense mutation in the gene. The wbpB gene product is a member of the Wbp pathway, which plays a role in the synthesis of UDP-ManNAc(3NAc)A in Pseudomonas aeruginosa; UDP-ManNAc(3NAc)A is sequentially synthesized by the WbpA, WbpB, WbpE, WbpD and WbpI proteins. We then determined the effect of the PGN-0002 gene, a wbpD homolog, on the biosynthesis of A-LPS. A PGN-0002-deficient mutant demonstrated an A-LPS biosynthesis deficiency. Taken together with previous studies, the present results suggest that the final product synthesized by the Wbp pathway is one of the sugar substrates necessary for the biosynthesis of A-LPS. | |||||||||||||||
| 書誌情報 |
Scientific Reports 巻 4, p. 5056, 発行日 2014-05-23 |
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| 出版者 | Nature Publishing Group | |||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1038/srep05056 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Scientific Reports, 4, 5056; 2014 | |||||||||||||||
