| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2015-07-01 |
| タイトル |
|
|
タイトル |
Susceptibility of muridae cell lines to ecotropic murine leukemia virus and the cationic amino acid transporter 1 viral receptor sequences: implications for evolution of the viral receptor |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CAT1 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Ecotropic murine leukemia virus |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Evolution |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Glycosylation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kakoki, Katsura
Shinohara, Akio
Izumida, Mai
Koizumi, Yosuke
Honda, Eri
Kato, Goro
Igawa, Tsukasa
Sakai, Hideki
Hayashi, Hideki
Matsuyama, Toshifumi
Morita, Tetsuo
Koshimoto, Chihiro
Kubo, Yoshinao
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Ecotropic murine leukemia viruses (Eco-MLVs) infect mouse and rat, but not other mammalian cells, and gain access for infection through binding the cationic amino acid transporter 1 (CAT1). Glycosylation of the rat and hamster CAT1s inhibits Eco-MLV infection, and treatment of rat and hamster cells with a glycosylation inhibitor, tunicamycin, enhances Eco-MLV infection. Although the mouse CAT1 is also glycosylated, it does not inhibit Eco-MLV infection. Comparison of amino acid sequences between the rat and mouse CAT1s shows amino acid insertions in the rat protein near the Eco-MLV-binding motif. In addition to the insertion present in the rat CAT1, the hamster CAT1 has additional amino acid insertions. In contrast, tunicamycin treatment of mink and human cells does not elevate the infection, because their CAT1s do not have the Eco-MLV-binding motif. To define the evolutionary pathway of the Eco-MLV receptor, we analyzed CAT1 sequences and susceptibility to Eco-MLV infection of other several murinae animals, including the southern vole (Microtus rossiaemeridionalis), large Japanese field mouse (Apodemus speciosus), and Eurasian harvest mouse ( Micromys minutus). Eco-MLV infection was enhanced by tunicamycin in these cells, and their CAT1 sequences have the insertions like the hamster CAT1. Phylogenetic analysis of mammalian CAT1s suggested that the ancestral CAT1 does not have the Eco-MLV-binding motif, like the human CAT1, and the mouse CAT1 is thought to be generated by the amino acid deletions in the third extracellular loop of CAT1. |
| 書誌情報 |
Virus Genes
巻 48,
号 3,
p. 448-456,
発行日 2014-06
|
| 出版者 |
|
|
出版者 |
Springer Netherlands |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09208569 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1572994X |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s11262-014-1036-1 |
| 権利 |
|
|
権利情報 |
c Springer Science+Business Media 2014. |
| 権利 |
|
|
権利情報 |
The final publication is available at link.springer.com |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Virus Genes, 48(3), pp.448-456; 2014 |
VirGen48_448.pdf (806.9 kB)
