WEKO3
アイテム
臓器指向性を有する自己組織化型薬物キャリアの開発とワクチンへの応用
http://hdl.handle.net/10069/39727
http://hdl.handle.net/10069/3972724f50438-a60f-40a9-91dc-e2172f5e983f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Yakugaku140_363.pdf (549.7 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2020-03-25 | |||||||
| タイトル | ||||||||
| タイトル | 臓器指向性を有する自己組織化型薬物キャリアの開発とワクチンへの応用 | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | cancer vaccine | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
黑﨑, 友亮
× 黑﨑, 友亮
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| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 2908 | |||||||
| 姓名 | Kurosaki, Tomoaki | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | Development of Vaccines with Self-assembled Carriers That Deliver Drugs to Target Organs | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | I have developed novel ternary complexes of various vaccines with cationic materials and anionic polymers. Plasmid DNA (pDNA) encoding firefly luciferase was used as a model drug to form adequate ternary complexes. Cationic binary complexes were constructed using pDNA and polyethylenimine, and these binary complexes were coated with various anionic polymers to form ternary complexes. These ternary complexes significantly improved cytotoxicity and aggregation with erythrocytes in comparison to the binary complexes. On the other hand, most of those ternary complexes showed little in vitro transgene efficiency because of their anionic surface charge. γ-Polyglutamic acid (γ-PGA)-ternary complexes, however, demonstrated high in vitro transgene efficiency. After the intravenous administration of γ-PGA-ternary complexes to mice, extremely high gene expression was detected in the marginal zone of the spleen, which is rich in antigen-presenting cells. This spleen-specific phenomenon of γ-PGA-ternary complexes appeared to be suited to DNA vaccines against cancer. I therefore examined the preventive effect of γ-PGA-ternary complexes containing pUb-M, a pDNA encoding melanoma surface antigen, against melanoma-bearing mice. Vaccinations of γ-PGA-ternary complexes into mice significantly suppressed the tumor growth of B16-F10 melanoma cells subcutaneously injected into the mice. In the same manner, vaccinations of γ-PGA-ternary complexes containing ovalbumin (OVA) completely suppressed the growth of E.G7-OVA cells expressing OVA. These results strongly suggest that γ-PGA-ternary complexes are useful in the manufacture of specific tumor vaccines. | |||||||
| 書誌情報 |
YAKUGAKU ZASSHI en : 薬学雑誌 巻 140, 号 3, p. 363-368, 発行日 2020-03-01 |
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| 出版者 | ||||||||
| 出版者 | 日本薬学会 | |||||||
| 出版社別言語 | ||||||||
| 値 | The Pharmaceutical Society of Japan | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 00316903 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 13475231 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1248/yakushi.19-00174 | |||||||
| 権利 | ||||||||
| 権利情報 | c 2020 The Pharmaceutical Society of Japan | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Yakugaku zasshi, 140(3), pp.363-368; 2020 | |||||||
