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Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women
http://hdl.handle.net/10069/34686
http://hdl.handle.net/10069/34686d2117d9b-d8b8-40b7-9b64-a8a8ef947bde
名前 / ファイル | ライセンス | アクション |
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CCLM52_289.pdf (139.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-01 | |||||
タイトル | ||||||
タイトル | Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carotid intima-media thickness | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glucokinase regulator protein gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sex difference | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Triglyceride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 2 diabetes mellitus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Murata-Mori, Fumi
× Murata-Mori, Fumi× Hayashida, Naomi× Ando, Takao× Ikeoka, Toshiyuki× Nakazato, Mio× Sekita, Harutaka× Abiru, Norio× Yamasaki, Hironori× Maeda, Takahiro× Kawakami, Atsushi× Takamura, Noboru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. Methods: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. Results: GCKR rs780094 AA genotype was significantly associated with higher TG (p < 0.001 vs. GG), lower HDL-C (p = 0.021 vs. GG), and lower HbA1c (p = 0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p = 0.001 vs. GX). These associations were seen only in men. Conclusions: GCKR rs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women. | |||||
書誌情報 |
Clinical Chemistry and Laboratory Medicine 巻 52, 号 2, p. 289-295, 発行日 2014-02 |
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出版者 | ||||||
出版者 | Walter de Gruyter GmbH & Co. KG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14346621 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14374331 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1515/cclm-2013-0092 | |||||
権利 | ||||||
権利情報 | c 2014 by Walter de Gruyter GmbH | |||||
権利 | ||||||
権利情報 | The final publication is available at www.degruyter.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical Chemistry and Laboratory Medicine, 52(2), pp.289-295; 2014 |