WEKO3
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Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning
http://hdl.handle.net/10069/34721
http://hdl.handle.net/10069/34721317d00dc-2941-4aab-ba3a-7ec1f067b57c
名前 / ファイル | ライセンス | アクション |
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JouImm11_246.pdf (247.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-01 | |||||
タイトル | ||||||
タイトル | Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dioxin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-17 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-1β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-22 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-23 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TH17 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNFα | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Yusho | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kuwatsuka, Yutaka
× Kuwatsuka, Yutaka× Shimizu, Kazuhiro× Akiyama, Yuichiro× Koike, Yuta× Ogawa, Fumihide× Furue, Masutaka× Utani, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Yusho poisoning incident, caused by rice oil contaminated with polychlorinated biphenyls (PCBs), polychlorinated quarterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) generated by heat-denatured PCBs, occurred in 1968 in western Japan. Although severe symptoms are rarely observed today, the levels of PCBs and PCDFs in the sera of Yusho patients remain high. The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity. Recent studies show that dioxin mediates its immune toxic effects via AhR and that AhR activation induces dysregulation of interleukin (IL)-17-producing T (TH17) cells. This study therefore hypothesized that Yusho patients would show dysregulated TH17 cell-mediated immune responses. To validate the hypothesis, levels of IL-17 and IL-22, each secreted by TH17 cells, along with IL-1β and IL-23 were measured in serum samples from 40 Yusho patients and 40 age-matched controls. Levels of tumor necrosis factor (TNF)-α potentially secreted by TH17 cell-stimulated neutrophils and macrophages were also measured. The results indicated that serum IL-17 levels, as well as those of IL-1β, IL-23, and TNFα, were significantly higher in Yusho patients than in controls. In contrast, serum IL-22 levels were significantly lower in the Yusho patients. These results suggest that Yusho patients have dysregulated TH17 cell-mediated immune responses that may be linked to inflammation. | |||||
書誌情報 |
Journal of Immunotoxicology 巻 11, 号 3, p. 246-249, 発行日 2014-07 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1547691X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15476901 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/1547691X.2013.835890 | |||||
権利 | ||||||
権利情報 | c 2014 Informa Healthcare USA, Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Immunotoxicology, 11(3), pp.246-249; 2014 |