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The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women
http://hdl.handle.net/10069/34732
http://hdl.handle.net/10069/3473271671433-d984-44b7-9709-54932a4736d0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TJEM233_149.pdf (381.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-10-01 | |||||
| タイトル | ||||||
| タイトル | The A>T Polymorphism of the Tribbles Homolog 1 Gene Is Associated with Serum Triglyceride Concentrations in Japanese Community-Dwelling Women | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Atherosclerosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dyslipidemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tribbles homolog 1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Triglyceride | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ikeoka, Toshiyuki
× Ikeoka, Toshiyuki× Hayashida, Naomi× Nakazato, Mio× Sekita, Takaharu× Murata-Mori, Fumi× Ando, Takao× Abiru, Norio× Yamasaki, Hironori× Kudo, Takashi× Maeda, Takahiro× Kawakami, Atsushi× Takamura, Noboru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent genome-wide association studies have identified Tribbles homolog 1 (TRIB1) as one of the candidate genes associated with lipid profiles. TRIB1 is known to interact with MAP kinases, thereby regulating their activities. The single nucleotide polymorphism rs2954029 of TRIB1 is located within an intron and is associated with lipid profiles. The aim of the present study is to investigate the TRIB1 rs2954029 (A>T polymorphism) with conventional predictors of coronary artery diseases such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), and with lipid profiles in general population. This study enrolled 2,581 Japanese adults, 942 men and 1,639 women with a median age of 68 years (range 29 to 94 years), who participated in a screening program for the general population living in Goto City, Nagasaki Prefecture, Japan from 2008 to 2010. For the determination of TRIB1 rs2954029 genotypes, the polymerase chain reaction method was used. The differences in each parameter among the TRIB1 rs2954029 genotypes were evaluated using analysis of covariance. Genotype frequencies of TRIB1 rs2954029 in all participants were 25.5% for AA, 50.4% for AT, and 24.0% for TT. In women, the AA genotype showed significantly higher log triglyceride (TG) concentrations than the AT genotype (P = 0.004) and the AT + TT genotypes (P = 0.004). On the other hand, there were no associations with CIMT and CAVI among the TRIB1 rs2954029 genotypes. In conclusion, the TRIB1 rs2954029 is associated with serum TG concentrations in Japanese community-dwelling women. | |||||
| 書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 233, 号 2, p. 149-153, 発行日 2014-06-06 |
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| 出版者 | ||||||
| 出版者 | 東北ジャーナル刊行会 | |||||
| 出版者別言語 | ||||||
| 値 | Tohoku University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00408727 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13493329 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1620/tjem.233.149 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 Tohoku University Medical Press. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Tohoku Journal of Experimental Medicine, 233(2), pp.149-153; 2014 | |||||
