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Efficacy of aerosolized liposomal amphotericin B against murine invasive pulmonary mucormycosis
http://hdl.handle.net/10069/34735
http://hdl.handle.net/10069/347355dd7d87f-2098-43c9-b3b3-103cd590447b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JIC20_104.pdf (822.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-10-03 | |||||
| タイトル | ||||||
| タイトル | Efficacy of aerosolized liposomal amphotericin B against murine invasive pulmonary mucormycosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Aerosolized liposomal amphotericin B | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mucormycosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prophylaxis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rhizopus oryzae | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Treatment | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Mihara, Tomo
× Mihara, Tomo× Kakeya, Hiroshi× Izumikawa, Koichi× Obata, Yoko× Nishino, Tomoya× Takazono, Takahiro× Kosai, Kosuke× Morinaga, Yoshitomo× Kurihara, Shintaro× Nakamura, Shigeki× Imamura, Yoshifumi× Miyazaki, Taiga× Tsukamoto, Misuzu× Yamamoto, Yoshihiro× Yanagihara, Katsunori× Tashiro, Takayoshi× Kohno, Shigeru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Invasive pulmonary mucormycosis is a life-threatening fungal infection encountered in immunocompromised patients. An intravenous high-dose lipid formulation of amphotericin B, such as liposomal amphotericin B (L-AMB), is the recommended treatment. The efficacy of inhaled L-AMB against mucormycosis has not been evaluated. We evaluated the efficacy of inhaled aerosolized L-AMB in murine invasive pulmonary mucormycosis. ICR female mice were immunosuppressed with cortisone acetate and cyclophosphamide and challenged on day 0 with 1 × 106 conidia of Rhizopus oryzae (TIMM 1327) intratracheally. Infected mice were assigned to one of the following 3 treatment groups: (i) control, (ii) treatment only (aerosolized L-AMB from day 1-5 after challenge), and (iii) prophylaxis followed by treatment (aerosolized L-AMB from day -2 to 5 before and after challenge). Survival was monitored until 12 days after challenge. For fungalburden and histopathological examination, mice were sacrificed 4 h after treatment on day 3. Numbers of colony-forming units per lung were calculated. To study the distribution of AMB after inhalation of L-AMB, immunohistochemical studies using AMB antibody were performed. Aerosolized L-AMB significantly improved survival rate and decreased fungal burden compared with control group, and histopathology findings were superior to those of control group. However, no significant differences were detected between the treatment-only and prophylaxis followed by treatment groups. Immunohistochemical analysis showed that L-AMB was promptly distributed in lung tissue after inhalation therapy. Aerosolized L-AMB showed modest efficacy against R. oryzae infection in mice treated after fungal challenge. Prophylaxis with aerosolized L-AMB was not effective in this animal model. | |||||
| 書誌情報 |
Journal of Infection and Chemotherapy 巻 20, 号 2, p. 104-108, 発行日 2014-02 |
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| 出版者 | ||||||
| 出版者 | 日本化学療法学会・日本感染症学会 | |||||
| 出版者別言語 | ||||||
| 値 | Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1341321X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jiac.2013.09.002 | |||||
| 権利 | ||||||
| 権利情報 | c 2013, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. | |||||
| 権利 | ||||||
| 権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection and Chemotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection and Chemotherapy, 20, 2, (2014) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Infection and Chemotherapy, 20(2), pp.104-108; 2014 | |||||
