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Identification and Characterization of Vancomycin-resistant Enterococcus species Frequently Isolated from Laboratory Mice
http://hdl.handle.net/10069/34747
http://hdl.handle.net/10069/3474761353f60-ab71-409c-bce9-301b93ccb9be
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ExAn63_297.pdf (571.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-10-03 | |||||
| タイトル | ||||||
| タイトル | Identification and Characterization of Vancomycin-resistant Enterococcus species Frequently Isolated from Laboratory Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ATP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Laboratory mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prevalence | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Vancomycin-resistant Enterococcus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Virulence factor | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamanaka, Hitoki
× Yamanaka, Hitoki× Takagi, Toshikazu× Ohsawa, Makiko× Yamamoto, Naoto× Kubo, Noriaki× Takemoto, Takahira× Sasano, Shoko× Masuyama, Ritsuko× Ohsawa, Kazutaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To determine the prevalence of drug resistant bacteria colonizing laboratory mice, we isolated and characterized vancomycin-resistant Enterococcus species (VRE) from commercially available mice. A total of 24 VRE isolates were obtained from 19 of 21 mouse strains supplied by 4 commercial breeding companies. Of these, 19 isolates of E. gallinarum and 5 isolates of E. casseliflavus possessing the vanC1 and vanC2/3 genes intrinsically, exhibited intermediate resistance to vancomycin respectively. In addition, these isolates also exhibited diverse resistant patterns to erythromycin, tetracycline, and ciprofloxacin, whereas the use of antibiotics had not been undertaken in mouse strains tested in this study. Although 6 virulence-associated genes (ace, asa, cylA, efaA, esp, and gelE) and secretion of gelatinase and hemolysin were not detected in all isolates, 23 of 24 isolates including the isolates of E. casselifalvus secreted ATP into culture supernatants. Since secretion of ATP by bacteria resident in the intestinal tract modulates the local immune responses, the prevalence of ATP-secreting VRE in mice therefore needs to be considered in animal experiments that alter the gut microflora by use of antibiotics. | |||||
| 書誌情報 |
Experimental Animals 巻 63, 号 3, p. 297-304, 発行日 2014-07-30 |
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| 出版者 | ||||||
| 出版者 | 日本実験動物学会 | |||||
| 出版者別言語 | ||||||
| 値 | Japanese Association for Laboratory Animal Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13411357 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18817122 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1538/expanim.63.297 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 Japanese Association for Laboratory Animal Science | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Experimental Animals, 63(3), pp.297-304; 2014 | |||||
