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Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience
http://hdl.handle.net/10069/35050
http://hdl.handle.net/10069/350501832209a-3dbc-4845-92d9-354b40082eea
名前 / ファイル | ライセンス | アクション |
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IJH100_464.pdf (308.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-01-26 | |||||
タイトル | ||||||
タイトル | Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adult T cell leukemia-lymphoma (ATL) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Elderly patients | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Makiyama, Junya
× Makiyama, Junya× Imaizumi, Yoshitaka× Tsushima, Hideki× Taniguchi, Hiroaki× Moriwaki, Yuji× Sawayama, Yasushi× Imanishi, Daisuke× Taguchi, Jun× Hata, Tomoko× Tsukasaki, Kunihiro× Miyazaki, Yasushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | VCAP (vincristine, cyclophosphamide, doxorubicin, and prednisone)-AMP (doxorubicin, ranimustine, and prednisone)-VECP (vindesine, etoposide, carboplatin, and prednisone) is a standard regimen for aggressive adult T cell leukemia-lymphoma (ATL). However, the efficacy of this regimen has not been fully elucidated for patients aged 70 years or older. Here, we retrospectively analyzed elderly patients with aggressive ATL at Nagasaki University Hospital between 1994 and 2010 to assess treatment outcomes. Of 148 evaluable patients, 54 were aged 70 years or older at diagnosis. The median survival time (MST) and overall survival (OS) at 2 years in elderly patients were 10.6 months and 22.1 %, respectively. Thirty-four patients received VCAP-AMP-VECP as the initial treatment, although the doses were reduced for most patients. In these patients, MST and OS at 2 years were 13.4 months and 26.6 %, respectively. Eleven of 34 patients (32 %) received maintenance oral chemotherapy after two or three cycles of VCAP-AMP-VECP, and MST and OS at 2 years were 16.7 months and 32.7 %, respectively. Our results suggest that the VCAP-AMP-VECP regimen may be effective and that maintenance oral chemotherapy may be considered as a therapeutic option for elderly patients with aggressive ATL. | |||||
書誌情報 |
International Journal of Hematology 巻 100, 号 5, p. 464-472, 発行日 2014-11 |
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出版者 | ||||||
出版者 | 日本血液学会 | |||||
出版者別言語 | ||||||
Japanese Society of Hematology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09255710 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18653774 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12185-014-1665-0 | |||||
権利 | ||||||
権利情報 | c The Japanese Society of Hematology 2014 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Hematology, 100(5), pp.464-472; 2014 |