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Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers
http://hdl.handle.net/10069/39791
http://hdl.handle.net/10069/3979128787755-f6d5-4b27-a153-8e3c41a03ddd
名前 / ファイル | ライセンス | アクション |
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RPaN277_103429.pdf (840.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-08 | |||||
タイトル | ||||||
タイトル | Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbon dioxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nasal high flow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Propofol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sedation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mishima, Gaku
× Mishima, Gaku× Sanuki, Takuro× Revie, James× Pinkham, Max× Watanabe, Toshihiro× Kurata, Shinji× Tatkov, Stanislav× Ayuse, Takao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. Methods: NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2. Results: During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO2 by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively. Conclusion: During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation. | |||||
書誌情報 |
Respiratory Physiology & Neurobiology 巻 277, p. 103429, 発行日 2020-03-12 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15699048 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.resp.2020.103429 | |||||
権利 | ||||||
権利情報 | c 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Respiratory Physiology and Neurobiology, 277, art.no.103429; 2020 |