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The development of regenerative medicine could improve this condition by regenerating impaired anal muscle. In order to prove this hypothesis, preliminary experiments in animals will be indispensable; however, an adequate animal model is currently lacking. The purpose of this study was to establish a novel animal model with long-term sustainable anal sphincter dysfunction. Materials and methods: Twenty male Sprague-Dawley rats were allocated into sham operation (n = 10) and anal sphincter resection (ASR) (n = 10) groups. The ASR group underwent removal of the left half of both the internal and external anal sphincters. Both groups were evaluated for anal function by measuring their resting pressure before surgery and on postoperative day (POD) 1, 7, 14, and 28. Results: The rats in the sham operation group recovered their anal pressure up to baseline on POD 7. 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A novel animal model of long-term sustainable anal sphincter dysfunction
http://hdl.handle.net/10069/33942
http://hdl.handle.net/10069/339424272d2aa-07f6-4c64-88e7-d409b04f9ed6
名前 / ファイル | ライセンス | アクション |
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JSR184_813.pdf (387.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-11-06 | |||||
タイトル | ||||||
タイトル | A novel animal model of long-term sustainable anal sphincter dysfunction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anal sphincter dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animal model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intersphincteric resection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regenerative medicine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamaguchi, Izumi
× Yamaguchi, Izumi× Fujita, Fumihiko× Yamanouchi, Kosho× Mishima, Takehiro× Kawahara, Daisuke× Sakai, Yusuke× Ito, Shinichiro× Kanetaka, Kengo× Takatsuki, Mitsuhisa× Kuroki, Tamotsu× Eguchi, Susumu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Although intersphincteric resection can avoid the need for permanent colostomy in patients with lower rectal cancer, it sometimes causes anal sphincter dysfunction, thus resulting in a lifelong, debilitating disorder due to incontinence of solid and liquid stool. The development of regenerative medicine could improve this condition by regenerating impaired anal muscle. In order to prove this hypothesis, preliminary experiments in animals will be indispensable; however, an adequate animal model is currently lacking. The purpose of this study was to establish a novel animal model with long-term sustainable anal sphincter dysfunction. Materials and methods: Twenty male Sprague-Dawley rats were allocated into sham operation (n = 10) and anal sphincter resection (ASR) (n = 10) groups. The ASR group underwent removal of the left half of both the internal and external anal sphincters. Both groups were evaluated for anal function by measuring their resting pressure before surgery and on postoperative day (POD) 1, 7, 14, and 28. Results: The rats in the sham operation group recovered their anal pressure up to baseline on POD 7. The rats in the ASR group showed a significant decrease in anal pressure on POD 1 (P < 0.0001) compared with the baseline, and kept this low pressure until POD 28 (P < 0.0001). The defect of the anal sphincter muscle was confirmed histologically in the ASR group on POD 28. Conclusions: The present novel model exhibits continuous anal sphincter dysfunction for at least 1 mo and may contribute to further studies evaluating the efficacy of therapies such as regenerative medicine. | |||||
書誌情報 |
Journal of Surgical Research 巻 184, 号 2, p. 813-818, 発行日 2013-10 |
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出版者 | ||||||
出版者 | Academic Press Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00224804 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jss.2013.04.010 | |||||
権利 | ||||||
権利情報 | © 2013 Elsevier Inc. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Surgical Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Surgical Research, 184, 2, (2013) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Surgical Research, 184(2), pp.813-818; 2013 |