| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-11-07 |
| タイトル |
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|
タイトル |
FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Autophagy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Degradation |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
FK506 |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Microglia; Prion |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Tacrolimus |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Therapy |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nakagaki, Takehiro
Satoh, Katsuya
Ishibashi, Daisuke
Fuse, Takayuki
Sano, Kazunori
Kamatari, Yuji O.
Kuwata, Kazuo
Shigematsu, Kazuto
Iwamaru, Yoshifumi
Takenouchi, Takato
Kitani, Hiroshi
Nishida, Noriyuki
Atarashi, Ryuichiro
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Prion diseases are fatal neurodegenerative disorders and no effective treatment has been established to date. In this study, we evaluated the effect of FK506 (tacrolimus), a macrolide that is known to be a mild immunosuppressant, on prion infection, using cell culture and animal models. We found that FK506 markedly reduced the abnormal form of prion protein (PRNPSc) in the cell cultures (N2a58 and MG20) infected with Fukuoka-1 prion. The levels of autophagy-related molecules such as LC3-II , ATG12-ATG5 and ATG7 were significantly increased in the FK506-treated cells, and resulted in the increased formation of autolysosomes. Upregulation of the autophagy-related molecules was also seen in the brains of FK506-treated mice and the accumulation of PRNPSc was delayed. The survival periods in mice inoculated with Fukuoka-1 were significantly increased when FK506 was administered from day 20 post-inoculation. These findings provide evidence that FK506 could constitute a novel antiprion drug, capable of enhancing the degradation of PRNPSc in addition to attenuation of microgliosis and neuroprotection. |
| 書誌情報 |
Autophagy
巻 9,
号 9,
p. 1386-1394,
発行日 2013-09
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| 出版者 |
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出版者 |
Landes Bioscience |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15548627 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.4161/auto.25381 |
| 権利 |
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|
権利情報 |
© 2013 Landes Bioscience. |
| 権利 |
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|
権利情報 |
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Autophagy, 9(9), pp.1386-1394; 2013 |
Aupha9_1386.pdf (1.1 MB)
