WEKO3
アイテム
Effect of switching from sevelamer hydrochloride to lanthanum carbonate on metabolic acidosis in dialysis patients
http://hdl.handle.net/10069/34058
http://hdl.handle.net/10069/3405853603db8-e068-438e-a6d8-4a6dab373536
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ActMed58_79.pdf (564.0 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-01-17 | |||||
| タイトル | ||||||
| タイトル | Effect of switching from sevelamer hydrochloride to lanthanum carbonate on metabolic acidosis in dialysis patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | earthquake disaster | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hemodialysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lanthanum carbonate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | metabolic acidosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sevelamer hydrochloride | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Minami, Kana
× Minami, Kana× Nishino, Tomoya× Arai, Hideyuki× Hirose, Misaki× Yamashita, Hiroshi× Uramatsu, Tadashi× Obata, Yoko× Funakoshi, Satoshi× Harada, Takashi× Kohno, Shigeru |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Treatments for hyperphosphatemia in dialysis patients include dietary therapy and oral administration of phosphate binders; however, it has recently been suggested that oral administration of sevelamer hydrochloride, a phosphate binder, may cause metabolic acidosis. Owing to the decreased supply of sevelamer hydrochloride after the Eastern Japan Great Earthquake Disaster on March 11, 2011, hyperphosphatemia patients switched to another phosphate binder, lanthanum carbonate. Here, we retrospectively evaluated the effect of this medication substitution on metabolic acidosis in patients on maintenance hemodialysis. 32 patients, who underwent maintenance hemodialysis at Nagasaki Kidney Center in Japan, were enrolled in our study and followed to evaluate the effect of switching medication on metabolic acidosis at 3 months after switching from sevelamer hydrochloride to lanthanum carbonate. The mean dose of sevelamer hydrochloride prior to the earthquake disaster was 3 g/day, and the mean dose of lanthanum carbonate thereafter was 0.9 g/day. Three months after the medication was changed, the concentration of bicarbonate ion did not increase significantly (p = 0.186), whereas pH and base excess increased significantly (p = 0.007 and p = 0.036, respectively). In this study, although the HCO3 - level was not significantly changed, the pH and base excess were significantly increased. Our findings indicate that lanthanum carbonate ameliorates metabolic acidosis. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 58, 号 3, p. 79-84, 発行日 2013-12 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Nagasaki University School of Medicine | |||||
| 出版者別言語 | ||||||
| 値 | 長崎大学医学部 | |||||
| sortkey | ||||||
| 値 | 03 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia, 58(3), pp.79-84; 2013 | |||||
