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Influence of Interferon-free Direct-acting Antiviral Therapy on Primary Hepatocellular Carcinoma Recurrence: A Landmark Time Analysis and Time-dependent Extended Cox Proportional Hazards Model Analysis
http://hdl.handle.net/10069/39889
http://hdl.handle.net/10069/39889a4135065-23fb-46f0-aa30-bf1aae470281
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IntMed59_901.pdf (628.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-04-24 | |||||
| タイトル | ||||||
| タイトル | Influence of Interferon-free Direct-acting Antiviral Therapy on Primary Hepatocellular Carcinoma Recurrence: A Landmark Time Analysis and Time-dependent Extended Cox Proportional Hazards Model Analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatitis C | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | direct-acting antivirals | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | recurrence | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | time interval | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Miuma, Satoshi
× Miuma, Satoshi× Miyamoto, Junya× Taura, Naota× Fukushima, Masanori× Sasaki, Ryu× Haraguchi, Masafumi× Shibata, Hidetaka× Sato, Shuntaro× Miyaaki, Hisamitsu× Nakao, Kazuhiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective The influence of interferon (IFN)-free direct-acting antiviral (DAA) on hepatocellular carcinoma (HCC) recurrence remains unclear. Previous retrospective analyses revealed that the time interval between HCC curative treatment and IFN-free DAA induction is the critical factor affecting HCC recurrence. Thus, this study aimed to examine the influence of DAA therapy on HCC recurrence considering this interval. Methods Factors contributing to HCC recurrence were retrospectively analyzed using a landmark time analysis and time-dependent extended Cox proportional hazards model. Patients After screening 620 patients who were diagnosed with primary HCC from January 2001 to December 2016, 76 patients with early-stage (primary and solitary) disease who received curative treatment and were positive for serum hepatitis C virus RNA were included. Results HCC recurrence was observed in 8 of 17 (47.1%) patients who had received IFN-free DAA therapy and 45 of 59 (76.3%) who had not. No significant difference was seen between the IFN-free DAA (-) and IFN-free DAA (+) groups in the landmark time and time-dependent Cox proportional hazards model analyses. However, IFN-free DAA therapy tended to decrease the HCC recurrence rate after curative treatment for primary HCC in patients with chronic hepatitis. In addition, IFN-free DAA therapy tended to decrease the second HCC recurrence rate after treatment for the first HCC recurrence. Conclusion Our results, with a consideration of the time interval between HCC curative treatment and IFN-free DAA induction, showed that IFN-free DAA therapy was not associated with early-stage HCC recurrence after curative treatment. | |||||
| 書誌情報 |
Internal Medicine 巻 59, 号 7, p. 901-907, 発行日 2020-04-01 |
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| 出版者 | ||||||
| 出版者 | Japanese Society of Internal Medicine | |||||
| 出版者別言語 | ||||||
| 値 | 日本内科学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09182918 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13497235 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2169/internalmedicine.3382-19 | |||||
| 権利 | ||||||
| 権利情報 | c 2020 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/ by-nc-nd/4.0/). |
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| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
