Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2020-05-01 |
タイトル |
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タイトル |
Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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主題 |
Alcohol drinking |
キーワード |
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主題Scheme |
Other |
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主題 |
Body mass index |
キーワード |
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主題Scheme |
Other |
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主題 |
Bone health |
キーワード |
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主題Scheme |
Other |
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主題 |
Current smoking |
キーワード |
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主題Scheme |
Other |
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主題 |
Sexes |
キーワード |
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主題Scheme |
Other |
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主題 |
Vitamin K |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Tanaka, Natsumi
Arima, Kazuhiko
Nishimura, Takayuki
Tomita, Yoshihito
Mizukami, Satoshi
Okabe, Takuhiro
Abe, Yasuyo
Kawashiri, Shin-ya
Uchiyama, Michiko
Honda, Yuzo
Tsujimoto, Ritsu
Kanagae, Mitsuo
Osaki, Makoto
Aoyagi, Kiyoshi
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND: An increase in serum undercarboxylated osteocalcin concentrations suggests vitamin K deficiency. Clinical intervention studies suggested that the vitamin K supplementation might contribute to preventing bone loss in postmenopausal women. Evidence on the relationship between serum undercarboxylated osteocalcin (ucOC) levels and bone parameters of quantitative ultrasound (QUS) is limited. We examined the correlation between serum ucOC concentrations and bone status as measured by QUS among middle-aged and older Japanese men and women. METHODS: The subjects were community-dwelling men (n = 358) and women (n = 503) aged ? 40?years in Japan. Heel QUS parameters, including the stiffness index, speed of sound, and broadband ultrasound attenuation, were measured. Serum ucOC concentrations were measured by electrochemiluminescence immunoassay. Grip strength was measured in the dominant hand. Information on alcohol drinking, current smoking, exercise, and menopause in women was collected. RESULTS: Serum ucOC concentrations were significantly associated with age in both sexes. Serum ucOC concentrations in men were higher at ? 80?years than those in the age groups of 40-49, 50-59, and 60-69?years. Serum ucOC concentrations in women were higher in the age groups of 50-59 and 60-69?years than those at 40-49?years. Partial correlation analysis adjusting for covariates (age, body mass index, grip strength, alcohol drinking, current smoking, and exercise in men; age, body mass index, grip strength, alcohol drinking, current smoking, exercise, and menopause in women) showed that serum ucOC concentrations were negatively significantly correlated with all QUS parameters in women. Serum ucOC concentrations were not correlated with them in men. CONCLUSIONS: Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women. |
書誌情報 |
Journal of Physiological Anthropology
巻 39,
号 1,
p. 9,
発行日 2020-04-10
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出版者 |
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出版者 |
BioMed Central Ltd. |
EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
18806805 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s40101-020-00221-1 |
権利 |
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権利情報 |
c The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commonslicence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commonslicence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtainpermission directly from the copyright holder. To view a copy of this licence,visit http://creativecommons.org/licenses/by/4.0/.The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
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内容記述タイプ |
Other |
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内容記述 |
Journal of physiological anthropology, 39(1), art.no.9; 2020 |