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Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid
http://hdl.handle.net/10069/32606
http://hdl.handle.net/10069/3260623fa7433-b573-42e6-b7e9-1364d42b8e41
名前 / ファイル | ライセンス | アクション |
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CanSci104_536.pdf (785.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-01 | |||||
タイトル | ||||||
タイトル | Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | isopentenyl diphosphate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myeloid cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitrogen-containing bisphosphonate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γδ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer immunotherapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Idrees, Atif S. M.
× Idrees, Atif S. M.× Sugie, Tomoharu× Inoue, Chiyomi× Murata-Hirai, Kaoru× Okamura, Haruki× Morita, Craig T.× Minato, Nagahiro× Toi, Masakazu× Tanaka, Yoshimasa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Exposing human tumor cells to nitrogen-containing bisphosphonates, such as zoledronic acid (Zol), greatly increases their susceptibility to killing by γδ T cells. Based on this finding and other studies, cancer immunotherapy using γδ T cells and nitrogen-containing bisphosphonates has been studied in pilot clinical trials and has shown benefits. Although Zol treatment can render a wide variety of human tumor cells susceptible to γδ T cell killing, there has not been a systematic investigation to determine which types of tumor cells are the most susceptible to γδ T cell-mediated cytotoxicity. In this study, we determined the Zol concentrations required to stimulate half maximal tumor necrosis factor-α production by γδ T cells cultured with various tumor cell lines pretreated with Zol and compared these concentrations with those required for half maximal inhibition of farnesyl diphosphate synthase (FPPS) in the same tumor cell lines. The inhibition of tumor cell growth by Zol was also assessed. We found that FPPS inhibition strongly correlated with γδ T cell activation, confirming that the mechanism underlying γδ T cell activation by Zol is isopentenyl diphosphate (IPP) accumulation due to FPPS blockade. In addition, we showed that γδ T-cell receptor-mediated signaling correlated with γδ T cell tumor necrosis factor-α production and cytotoxicity. Some lymphoma, myeloid leukemia, and mammary carcinoma cell lines were relatively resistant to Zol treatment, suggesting that assessing tumor sensitivity to Zol may help select those patients most likely to benefit from immunotherapy with γδ T cells. | |||||
書誌情報 |
Cancer Science 巻 104, 号 5, p. 536-542, 発行日 2013-05 |
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出版者 | ||||||
出版者 | 日本癌学会 | |||||
出版者別言語 | ||||||
Japanese Cancer Association | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13479032 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/cas.12124 | |||||
権利 | ||||||
権利情報 | © 2013 Japanese Cancer Association | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Science, 104(5), pp.536-542; 2013 |