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Protective effects of a cystine and theanine mixture against acute radiation injury in rats
http://hdl.handle.net/10069/39974
http://hdl.handle.net/10069/39974dcd06f95-44f4-4276-b965-6fb844aa5af1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ETP78_103395.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-18 | |||||
| タイトル | ||||||
| タイトル | Protective effects of a cystine and theanine mixture against acute radiation injury in rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cystine and theanine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Jejunum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone marrow | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Radiation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsuu-Matsuyama, Mutsumi
× Matsuu-Matsuyama, Mutsumi× Shichijo, Kazuko× Tsuchiya, Takashi× Kondo, Hisayoshi× Miura, Shiro× Matsuda, Katsuya× Sekine, Ichiro× Nakashima, Masahiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aims to examine the effects of cystine and theanine (CT), which increases glutathione biosynthesis, on the survival rate and acute radiation injury of the small intestine and bone marrow using a rat model. CT pre-treatment (280 mg/kg for 5 days) significantly improved weight loss and survival rate of rats as compared with the control group after 5 Gy. CT pre-treatment significantly increased the rate of mucosa and crypt length, and decreased the number of apoptotic cells, TUNEL and cleaved caspase-3 positive cells, while increasing the number of mitotic cells and Ki-67 positive cells in jejunal crypts and villi compared to control rats post-irradiation. CT also suppressed bone marrow cell loss and reduced the number of apoptotic cells in bone marrow. These results suggest a protective effect of CT pre-treatment for acute injury after irradiation through apoptosis inhibition and increased proliferative activity in jejunal crypt cells and bone marrow cells. | |||||
| 書誌情報 |
Environmental Toxicology and Pharmacology 巻 78, p. 103395, 発行日 2020-04-17 |
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| 出版者 | ||||||
| 出版者 | Elsevier B.V. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13826689 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.etap.2020.103395 | |||||
| 権利 | ||||||
| 権利情報 | c 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Environmental Toxicology and Pharmacology, 78, art.no.103395; 2020 | |||||
