WEKO3
アイテム
{"_buckets": {"deposit": "511c6ad7-0d21-4e26-b1f0-a61e4ddb0c07"}, "_deposit": {"created_by": 2, "id": "8385", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "8385"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00008385", "sets": ["74"]}, "author_link": ["34213", "34214", "34216", "34215"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-10-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "453", "bibliographicPageStart": "434", "bibliographicVolumeNumber": "88", "bibliographic_titles": [{"bibliographic_title": "Proceedings of the Japan Academy, Series B"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogenactivated protein kinase kinase kinase (MAP3K) family that activates downstream MAP kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs, in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide, and calcium overload. Activation of the JNK and p38 pathways induces stress responses such as cell death, differentiation, and the production of inflammatory cytokines. A series of studies using ASK1-deficient mice have indicated that ASK1 plays important roles in many stress-related diseases, including cardiovascular and neurodegenerative diseases, suggesting that small compounds that inhibit ASK1 activity could possibly be used for the amelioration of the development and/or progression of these diseases. In this review, we provide an overview of the pathophysiological roles of ASK1-dependent signaling pathways and discuss the mechanistic basis for how these could serve as potential therapeutic targets.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Proceedings of the Japan Academy, Series B, 88(8), pp.434-453; 2012", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本学士院"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2183/pjab.88.434", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012 The Japan Academy."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03862208", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13492896", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "Japan Academy"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayakawa, Ryoichi"}], "nameIdentifiers": [{"nameIdentifier": "34213", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayakawa, Teruyuki"}], "nameIdentifiers": [{"nameIdentifier": "34214", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Kohsuke"}], "nameIdentifiers": [{"nameIdentifier": "34215", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichijo, Hidenori"}], "nameIdentifiers": [{"nameIdentifier": "34216", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PJAB88_434.pdf", "filesize": [{"value": "732.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 732600.0, "url": {"label": "PJAB88_434.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/8385/files/PJAB88_434.pdf"}, "version_id": "9e0bfd1c-f36c-4699-ad6e-e593d77229f1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Ask1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inhibitors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MAP kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Signal transduction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Stress", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Therapeutic targets in the ASK1-dependent stress signaling pathways", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Therapeutic targets in the ASK1-dependent stress signaling pathways"}]}, "item_type_id": "2", "owner": "2", "path": ["74"], "permalink_uri": "http://hdl.handle.net/10069/31142", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-03-29"}, "publish_date": "2013-03-29", "publish_status": "0", "recid": "8385", "relation": {}, "relation_version_is_last": true, "title": ["Therapeutic targets in the ASK1-dependent stress signaling pathways"], "weko_shared_id": -1}
Therapeutic targets in the ASK1-dependent stress signaling pathways
http://hdl.handle.net/10069/31142
http://hdl.handle.net/10069/3114231fcdad4-c914-4ecb-a037-6cb4e59f7c3f
名前 / ファイル | ライセンス | アクション |
---|---|---|
PJAB88_434.pdf (732.6 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-03-29 | |||||
タイトル | ||||||
タイトル | Therapeutic targets in the ASK1-dependent stress signaling pathways | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ask1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MAP kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hayakawa, Ryoichi
× Hayakawa, Ryoichi× Hayakawa, Teruyuki× Takeda, Kohsuke× Ichijo, Hidenori |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogenactivated protein kinase kinase kinase (MAP3K) family that activates downstream MAP kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs, in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide, and calcium overload. Activation of the JNK and p38 pathways induces stress responses such as cell death, differentiation, and the production of inflammatory cytokines. A series of studies using ASK1-deficient mice have indicated that ASK1 plays important roles in many stress-related diseases, including cardiovascular and neurodegenerative diseases, suggesting that small compounds that inhibit ASK1 activity could possibly be used for the amelioration of the development and/or progression of these diseases. In this review, we provide an overview of the pathophysiological roles of ASK1-dependent signaling pathways and discuss the mechanistic basis for how these could serve as potential therapeutic targets. | |||||
書誌情報 |
Proceedings of the Japan Academy, Series B 巻 88, 号 8, p. 434-453, 発行日 2012-10-11 |
|||||
出版者 | ||||||
出版者 | 日本学士院 | |||||
出版者別言語 | ||||||
Japan Academy | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03862208 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13492896 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2183/pjab.88.434 | |||||
権利 | ||||||
権利情報 | © 2012 The Japan Academy. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Proceedings of the Japan Academy, Series B, 88(8), pp.434-453; 2012 |