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Effects of Nasal Continuous Positive Airway Pressure on the Glomerular Filtration Rate in Patients with Obstructive Sleep Apnea Syndrome
http://hdl.handle.net/10069/31487
http://hdl.handle.net/10069/314878d68095f-401b-4de4-ba7f-c78bf1ab0754
| 名前 / ファイル | ライセンス | アクション |
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IntMed52_345.pdf (251.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2013-04-24 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Effects of Nasal Continuous Positive Airway Pressure on the Glomerular Filtration Rate in Patients with Obstructive Sleep Apnea Syndrome | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Chronic kidney disease | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Continuous positive airway pressure | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Glomerular filtration rate | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Obstructive sleep apnea | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Koga, Seiji
× Koga, Seiji
× Ikeda, Satoshi
× Yasunaga, Tomohiko
× Nakata, Tomoo
× Maemura, Koji
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Objective Previous studies have shown a possible role for obstructive sleep apnea syndrome (OSAS) in the development and/or progression of chronic kidney disease (CKD). However, the impact of treatment for OSAS on CKD has not been clarified. The aim of this study was to investigate the influence of OSAS and the short-term effects of nasal continuous positive airway pressure (CPAP) on the estimated glomerular filtration rate (eGFR). Methods We evaluated 38 men with OSAS diagnosed on polysomnography. The associations between the eGFR and patient characteristics, including polysomnographic parameters, were evaluated. A multivariate linear regression analysis was performed to determine the independent variables associated with eGFR. We reassessed the polysomnographic data and eGFR values after three months of CPAP treatment. Results The mean serum creatinine level was 0.83±0.10 mg/dL and the mean eGFR was 77.3±12.0 mL/ min/1.73 m2. A univariate analysis revealed that an older age (p<0.001), a longer mean apnea duration (p= 0.006) and BMI (p=0.022) were significantly associated with lower eGFRs. A multivariate linear regression analysis showed that the independent factors associated with lower eGFRs were older age (p<0.001) and a longer mean apnea duration (p=0.048). Three months after CPAP treatment, there were significant decreases in the serum creatinine levels (p=0.013) and increases in eGFR (p=0.014). Conclusion OSAS, especially that associated with an older age and a longer mean apnea duration, may contribute to lowering eGFR values, which can be reversed by CPAP treatment. | |||||||||||||||
| 書誌情報 |
Internal Medicine 巻 52, 号 3, p. 345-349, 発行日 2013-02-01 |
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| 出版者 | ||||||||||||||||
| 出版者 | 日本内科学会 | |||||||||||||||
| 出版者別言語 | ||||||||||||||||
| Japanese Society of Internal Medicine | ||||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 09182918 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA10827774 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.2169/internalmedicine.52.8468 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | © 2013 The Japanese Society of Internal Medicine. | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Internal Medicine, 52(3), pp.345-349; 2013 | |||||||||||||||
