WEKO3
アイテム
Senemorphism: a novel perspective on aging patterns and its implication for diet-related biology
http://hdl.handle.net/10069/30228
http://hdl.handle.net/10069/3022827111b96-b400-4c23-a290-807e519107c8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Bio13_457.pdf (376.3 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-01-15 | |||||
| タイトル | ||||||
| タイトル | Senemorphism: a novel perspective on aging patterns and its implication for diet-related biology | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Biomarkers | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Caloric restriction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Evolution | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Longevity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Senemorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Senescence | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Trindade, Lucas Siqueira
× Trindade, Lucas Siqueira× Balduino, Alex× Aigaki, Toshiro× Heddle, Jonathan G. |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aging can be described as the accumulation of changes in organisms over time. Aging in organisms undergoing caloric restriction (CR) is widely considered as a slowed version of aging under ad libitum (AL) conditions. However, here we argue that aging under optimized CR is fundamentally different from aging under AL based on the following facts: (1) Comparing the two dietary groups, several age-related changes run in the opposite direction over time; (2) Switching from an AL to a CR diet clearly reverts (not only delays) several "normal" accumulated changes; (3) major causes of death are as different between both groups as they are between species. These observations support the idea that CR and AL initially modulate different metabolic and physiological programs, which exclusively over time generate two biologically different organisms. Such distinct diet-related senescence is analogous to the divergent aging processes and causes of death observed between castes of social insects, such as queens versus workers ("caste-related-senescence") and also between breeding versus non-breeding semelparous animals ("reproduction-related-senescence"). All these aging phenotypes are different not because they accumulate changes at a different rate, but because they accumulate different changes over time. Thus, the environment does not simply affect the individual aging rate through stochastic effects (e.g. U.V.) but also modulates the activation of a particular program/strategy that influences lifespan (e.g. caste, calorie intake). We refer to the environment-dependent aging patterns encoded by the genome as "senemorphism". Based on this idea we propose experimental schemes for aging, evolution and biomedical research. | |||||
| 書誌情報 |
Biogerontology 巻 13, 号 4, p. 457-466, 発行日 2012-08 |
|||||
| 出版者 | ||||||
| 出版者 | Springer Netherlands | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13895729 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15736768 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s10522-012-9383-6 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2012. This article is published with open access at Springerlink.com | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biogerontology, 13(4), pp.457-466; 2012 | |||||
