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ミニブタの同種末梢血リンパ球前処置による in vitro IL-2様活性の早期検出
http://hdl.handle.net/10069/18946
http://hdl.handle.net/10069/1894622e9650f-33be-41be-9e4d-ad9e5efcb203
名前 / ファイル | ライセンス | アクション |
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VMS53_3_365_369.pdf (496.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-11 | |||||
タイトル | ||||||
タイトル | ミニブタの同種末梢血リンパ球前処置による in vitro IL-2様活性の早期検出 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-2-like activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vitro assay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | miniature swine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monitor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
田浦, 保穂
× 田浦, 保穂× 角田, 司× 塩竃, 利昭× Mullen, Yoko× Papoian, Tom |
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著者別名 | ||||||
姓名 | Taura, Yasuho | |||||
著者別名 | ||||||
姓名 | Tsunoda, Tsukasa | |||||
著者別名 | ||||||
姓名 | Shiogama, Toshiaki | |||||
その他のタイトル | ||||||
その他のタイトル | Early In Vitro Detection of Interleukin-2-Like Activities by Pretreatment with Allogeneic Blood Lymphocytes in Miniature Swine | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ミニブタの同種移植における免疫反応の指標を得る目的で, ドナー末梢血リンパ球(PBL)前処置した後, ドナーPBLに対する in vitroでのIL-2様活性の測定を行い, 以下の結果が得られた: (1)MHC不適合無処置群の48時間MLC上清中にIL-2様活性がみられ, 48時間培養の方が高値であった; (2)MHC不適合PBLを1回移植した群は, 無処置群よりも in vitroでのIL-2様活性は高値であった; (3)MHC不適合PBLを週1回計4回移植した群は, in vitroでのIL-2様活性の検出がやや早期に認められた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In order to determine the means of monitoring the immunological status of allograft recipients in miniature swine, an assay was developed to measure interleukin (IL)-2 production in vitro by pretreatment of donor peripheral blood lymphocytes (PBL). Miniature swine were given 0 to 4 weekly intravenous transfusions of 5-10×10^7 donor PBL incompatible at major histocompatibility complex (MHC) and assayed in vitro for donor specific immune IL-2-like activities. The results are summarized as follows: (1) IL-2-like activity in 24 hr and 48 hr supernatants from mixed lymphocyte cultures (MLC) with MHC-incompatible PBL was detected without pretreatment. The 48 hr MLC supernatant exhibited a high IL-2-like activity compared with the 24 hr; (2) IL-2-like activity after only one transfusion with MHC-incompatible PBL was higher than that without pretreatment; (3) IL-2-like activity in 4 weekly transfusions was detectable slightly earlier than that without pretreatment or three transfusions with MHC-incompatibile PBL. | |||||
書誌情報 |
The journal of veterinary medical science 巻 53, 号 3, p. 365-369, 発行日 1991-06-15 |
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出版者 | ||||||
出版者 | 社団法人日本獣医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10796138 | |||||
権利 | ||||||
権利情報 | 社団法人日本獣医学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The journal of veterinary medical science. 1991, 53(3), p.365-369 |