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Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia
http://hdl.handle.net/10069/16175
http://hdl.handle.net/10069/161752f781153-6454-482d-96ea-678ec43e0019
名前 / ファイル | ライセンス | アクション |
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acta46_01_03_t.pdf (668.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphodiesterase III inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | End-systolic pressure-volume relationship | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | preload recruitable stroke work | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ventriculoarterial coupling | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tada, Seiichi
× Tada, Seiichi× Eishi, Kiyoyuki× Noguchi, Manabu× Hazama, Shirou× Iwamatsu, Miyoko× Taniguchi, Shinichirou |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the ventricular mechanical effects of PhosphodiesteraseIII (PDEIII) inhibitors in the failed heart after global ischemia induced by ventricular fibrillation (VF) using the left ventricular pressure-volume relationship (PVR). In 14 anesthetized open-chest dogs, left ventricular PVR was measured using a conductance catheter. Under administration of milrinone (MIL, n=7) and olprinone (OLP, n=7), the slopes of the LV end-systolic pressure-volume (Emax), arterial end-systolic pressure-stroke volume relations (Ea), ventriculoarterial coupling (Ea/Emax) and preload recruitable stroke work (PRSW) were obtained to evaluate changes in LV performance. The duration of VF was 1 min without cardiopulmonary bypass (CPB). OLP and MIL significantly increased the Emax and PRSW values in the failed heart after VF, and there was no dose-effect relationship at MIL doses of 0.25 to 0.75ホシg/kg/min or at OLP doses of 0.1 to 0.3ホシg/kg/min. The Ea/Emax value after VF was significantly lower in the presence of OLP or MIL than in the absence of these drugs (-45.3% with OLP and -46.5% with MIL). The results indicate that in the heart after transient global ischemia, both OLP and MIL improve hemodynamic and mechanical states in terms of ventriculoarterial coupling. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 46, 号 1-2, p. 15-20, 発行日 2001-06-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00015-P00020 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2001, 46(1-2), p.15-20 |