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Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans.
http://hdl.handle.net/10069/27425
http://hdl.handle.net/10069/27425be09d27c-4f0f-417f-b18e-6dfb3bd20c1c
名前 / ファイル | ライセンス | アクション |
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FEMS321_175.pdf (313.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-09-01 | |||||
タイトル | ||||||
タイトル | Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aggregatibacter actinomycetemcomitans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LFA-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neutrophil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Resistin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Src family tyrosine kinase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Furugen, Reiko
× Furugen, Reiko× Hayashida, Hideaki× Yoshii, Yumiko× Saito, Toshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Resistin is an adipokine that induces insulin resistance in mice. In humans, resistin is not produced in adipocytes, but in various leukocytes instead, and it acts as a proinflammatory molecule. The present investigation demonstrated high levels of resistin in culture supernatants of neutrophils that are stimulated by a highly leukotoxic strain of Aggregatibacter actinomycetemcomitans. In contrast, the level of resistin was remarkably low when neutrophils were exposed to two other strains that produce minimal levels of leukotoxin and a further isogenic mutant strain incapable of producing leukotoxin. Pretreatment of neutrophils with a monoclonal antibody to CD18, β chain of lymphocyte function-associated molecule 1 (LFA-1), or an Src family tyrosine kinase inhibitor before incubation with the highly leukotoxic strain inhibited the release of resistin. These results show that A. actinomycetemcomitans-expressed leukotoxin induces extracellular release of human neutrophil-derived resistin by interacting with LFA-1 on the surface of neutrophils and, consequently, activating Src family tyrosine kinases. | |||||
書誌情報 |
FEMS Microbiology Letters 巻 321, 号 2, p. 175-182, 発行日 2011-08 |
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出版者 | ||||||
出版者 | Blackwell Publishing Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03781097 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15746968 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00193861 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21658109 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1574-6968.2011.02334.x | |||||
権利 | ||||||
権利情報 | © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEMS Microbiology Letters, 321(2), pp.175-182; 2011 |