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Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.
http://hdl.handle.net/10069/20125
http://hdl.handle.net/10069/20125dee9edd1-5dab-4691-9a0e-9a19af7fb355
名前 / ファイル | ライセンス | アクション |
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ajtmh70_461.pdf (105.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-10-21 | |||||
タイトル | ||||||
タイトル | Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Huaman, Maria Cecilia
× Huaman, Maria Cecilia× Roncal, Norma× Nakazawa, Shusuke× Long, Ton That Ai× Gerena, Lucia× Garcia, Coralith× Solari, Lely× Magill, Alan J.× Kanbara, Hiroji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In vitro drug sensitivity to chloroquine (CQ), mefloquine (MQ) and quinine was investigated in 60 culture-adapted Plasmodium falciparum isolates from malaria patients in Padrecocha, a village in the Amazonian Department of Loreto, Peru. All isolates showed resistance to CQ, decreased susceptibility to quinine, and sensitivity to MQ. These isolates were examined for mutations in the P. falciparum multidrug resistance 1 (pfmdr1) and chloroquine resistance transporter (pfcrt) genes previously linked to CQ resistance. The mutations N86Y and D1246Y, two of the five mutations commonly observed in the pfmdr1 gene of CQ-resistant clones, were not found. The pfcrt mutation K76T, associated with CQ resistance, was identified in all the isolates tested. Sequence analysis of codons 72-76 in the pfcrt gene showed the haplotypes SVMNT and CVMNT. | |||||
書誌情報 |
American Journal of Tropical Medicine and Hygiene 巻 70, 号 5, p. 461-466, 発行日 2004-05 |
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出版者 | ||||||
出版者 | American Society of Tropical Medicine and Hygiene | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00029637 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00521439 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15155976 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2004 by The American Society of Tropical Medicine and Hygiene | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://www.ajtmh.org/cgi/content/abstract/70/5/461 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | American Journal of Tropical Medicine and Hygiene, 70(5), pp.461-466; 2004 |