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ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析
http://hdl.handle.net/10069/4394
http://hdl.handle.net/10069/43947a35b018-935d-4577-a931-ca6b50287f27
名前 / ファイル | ライセンス | アクション |
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tm26_04_06_t.pdf (345.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
藤原, 真理子
× 藤原, 真理子× 范, 育仁× 小坂, 光男× Ye, Win |
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著者別名 | ||||||
姓名 | Fujiwara, Mariko | |||||
著者別名 | ||||||
姓名 | Fan, Yu-Jen | |||||
著者別名 | ||||||
姓名 | Ye, Win | |||||
著者別名 | ||||||
姓名 | Kosaka, Mitsuo | |||||
その他のタイトル | ||||||
その他のタイトル | An Analysis of Fever-curves due to the Intravenous vs. Intraventricular Administration of LPS Pyrogen in Rabbits | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 大腸菌由来のlipopolysaccharide (LPS)を用いて,ウサギの発熱曲線の解折を行った.ウサギに体重1kgあたり0.2μgのLPS pyrogenを耳介皮膚血管から静脈内投与すると,10分から30分の短い潜時ののちに,二峰性の発熱が観察された.ところが,同濃度のpyrogenの側脳室への直接注入では,約1時間の潜時で,直腸温の上昇も1.5℃から2.0℃と,pyrogen静注時に比較すると高い一峰性の発熱が生じた.投与部位の差異による発熱パターンの違いから,LPS pyrogenの作用部位とその働きについて考察を加えた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Fever-curves were compared on response to injection of bacterial pyrogen into conscious rabbits using different routes of administration. Intravenous application of 0.2μg/kg LPS pyrogen to the rabbit was characterized by biphasic fever after a short delay of 10 to 30 minutes. However, monophasic fever developed when same dosage of LPS was administrated into the lateral-ventricular region. Its latency of fever onset was about 60 minutes with rectal temperature elevating by 1.5 to 2.0℃, and these febrile states continued for more than 5 hours. Based on these results, sites of pyrogen action and their underlying mechanisms were discussed in this paper. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 26, 号 4, p. 187-190, 発行日 1984-12-28 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00187-P00190 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 26(4). p187-190, 1984 |