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Materials and methods The anti-tumour effects and adverse events were evaluated in 163 MIBC patients who received systemic chemotherapy (SC, n = 34), intra-arterial chemotherapy (IAC, n = 50), or combined IAC and radiotherapy (IAC + R, n = 79). Results Pathological complete responses were observed in 17.6%, 22.0%, and 43.0% of patients in the SC, IAC, and IAC + R groups, respectively, with respective 5-year overall survival rates of 42.0%, 46.7%, and 50.3%. Multivariate analysis showed that successful IAC + R protocol administration was a significant predictor for survival (hazard ratio = 0.16, p = 0.028). The incidence of severe adverse events was higher in the IAC + R group (36.7%) than in the SC (9.8%) and IAC groups (16.0%). Conclusions IAC + R was useful for patients with MIBC. 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Efficacy and safety of systemic chemotherapy and intra-arterial chemotherapy with/without radiotherapy for bladder preservation or as neo-adjuvant therapy in patients with muscle-invasive bladder cancer: A single-centre study of 163 patients
http://hdl.handle.net/10069/35162
http://hdl.handle.net/10069/3516292845da5-5278-4a5d-a02e-02aec4b891f6
名前 / ファイル | ライセンス | アクション |
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EJSO41_361.pdf (858.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-03-31 | |||||
タイトル | ||||||
タイトル | Efficacy and safety of systemic chemotherapy and intra-arterial chemotherapy with/without radiotherapy for bladder preservation or as neo-adjuvant therapy in patients with muscle-invasive bladder cancer: A single-centre study of 163 patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adverse events | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bladder cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Preoperative treatment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiotherapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyata, Yasuyoshi
× Miyata, Yasuyoshi× Nomata, Koichiro× Ohba, K.× Matsuo, T.× Hayashi, N.× Sakamoto, I.× Uetani, M.× Sakai, H. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction Patients with muscle-invasive bladder cancer (MIBC) often undergo various preoperative treatments to improve survival; however, their efficacy and safety remain unclear. Materials and methods The anti-tumour effects and adverse events were evaluated in 163 MIBC patients who received systemic chemotherapy (SC, n = 34), intra-arterial chemotherapy (IAC, n = 50), or combined IAC and radiotherapy (IAC + R, n = 79). Results Pathological complete responses were observed in 17.6%, 22.0%, and 43.0% of patients in the SC, IAC, and IAC + R groups, respectively, with respective 5-year overall survival rates of 42.0%, 46.7%, and 50.3%. Multivariate analysis showed that successful IAC + R protocol administration was a significant predictor for survival (hazard ratio = 0.16, p = 0.028). The incidence of severe adverse events was higher in the IAC + R group (36.7%) than in the SC (9.8%) and IAC groups (16.0%). Conclusions IAC + R was useful for patients with MIBC. Successful completion and optimal patient selection were important for this treatment strategy. | |||||
書誌情報 |
European Journal of Surgical Oncology (EJSO) 巻 41, 号 3, p. 361-367, 発行日 2015-03 |
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出版者 | ||||||
出版者 | W.B. Saunders Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07487983 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejso.2014.07.043 | |||||
権利 | ||||||
権利情報 | c 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Surgical Oncology (EJSO), 41(3), pp.361-367; 2015 |