WEKO3
アイテム
{"_buckets": {"deposit": "b0e0b483-72dc-411f-b7cd-a2a852eafb67"}, "_deposit": {"created_by": 2, "id": "5282", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "5282"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00005282", "sets": ["9"]}, "author_link": ["22144", "22150", "22149", "22148", "22143", "22146", "22147", "22145", "22151"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "239", "bibliographicPageStart": "236", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Pancreas"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "OBJECTIVES: Zinc (Zn) is related to insulin synthesis, storage, and secretion. This study demonstrates the effects of Zn supplementation in donor rats on the outcomes of islet transplantation. METHODS: Donor rats received 3 different regimens of dietary Zn supplementation for 2 weeks before undergoing pancreas donation: a standard diet containing Zn at 50 ppm (control), 1 ppm (low-Zn group) or 1000 ppm (high-Zn group), respectively. Diabetic recipient rats underwent islet transplantation, and the blood glucose levels and insulin secretion were monitored for 7 days after transplantation. RESULTS: The serum and pancreatic Zn levels at the time of donation were significantly lower in the low-Zn group (48.8 ± 25.5 μg/dL and 11.3 ± 1.9 μg/g) and higher in the high-Zn group (147.3 ± 17.6 μg/dL and 18.7 ± 2.2 μg/g) when compared with those observed in the controls (118.7 ± 7.9 μg/dL and 14.6 ± 2.0 μg/g) (P \u003c 0.05). The blood glucose levels became re-elevated 2 days after transplantation in rats receiving islet grafts from the controls and the low-Zn groups. In contrast, in the rats that received islets from the high-Zn groups, these were maintained within a reference range (P \u003c 0.01). CONCLUSIONS: These data indicate that a Zn-rich diet for donor rats improves the function of islet grafts in chemically induced diabetic rats.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Pancreas, 43(2), pp.236-239; 2014", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Lippincott Williams and Wilkins"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1097/MPA.0000000000000093", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2014 by Lippincott Williams and Wilkins."}, {"subitem_rights": "This is a non-final version of an article published in final form in Pancreas, 43(2), pp.236-239; 2014"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "08853177", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mishima, Takehiro"}], "nameIdentifiers": [{"nameIdentifier": "22143", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroki, Tamotsu"}], "nameIdentifiers": [{"nameIdentifier": "22144", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tajima, Yoshitsugu"}], "nameIdentifiers": [{"nameIdentifier": "22145", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Adachi, Tomohiko"}], "nameIdentifiers": [{"nameIdentifier": "22146", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirabaru, Masataka"}], "nameIdentifiers": [{"nameIdentifier": "22147", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "22148", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitasato, Amane"}], "nameIdentifiers": [{"nameIdentifier": "22149", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takatsuki, Mitsuhisa"}], "nameIdentifiers": [{"nameIdentifier": "22150", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "22151", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Pancreas43_236.pdf", "filesize": [{"value": "284.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 284300.0, "url": {"label": "Pancreas43_236.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/5282/files/Pancreas43_236.pdf"}, "version_id": "16c08eb9-4177-41cf-badc-2f72e9963c07"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "dietary supplementation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "graft function", "subitem_subject_scheme": "Other"}, {"subitem_subject": "islet transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "type 1 diabetes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "zinc", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats"}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/34340", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-04-01"}, "publish_date": "2015-04-01", "publish_status": "0", "recid": "5282", "relation": {}, "relation_version_is_last": true, "title": ["Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats"], "weko_shared_id": -1}
Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats
http://hdl.handle.net/10069/34340
http://hdl.handle.net/10069/343407357a737-293b-4cd1-9fa8-f843fee6eb75
名前 / ファイル | ライセンス | アクション |
---|---|---|
Pancreas43_236.pdf (284.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-04-01 | |||||
タイトル | ||||||
タイトル | Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dietary supplementation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | graft function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | islet transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | type 1 diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | zinc | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mishima, Takehiro
× Mishima, Takehiro× Kuroki, Tamotsu× Tajima, Yoshitsugu× Adachi, Tomohiko× Hirabaru, Masataka× Tanaka, Takayuki× Kitasato, Amane× Takatsuki, Mitsuhisa× Eguchi, Susumu |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVES: Zinc (Zn) is related to insulin synthesis, storage, and secretion. This study demonstrates the effects of Zn supplementation in donor rats on the outcomes of islet transplantation. METHODS: Donor rats received 3 different regimens of dietary Zn supplementation for 2 weeks before undergoing pancreas donation: a standard diet containing Zn at 50 ppm (control), 1 ppm (low-Zn group) or 1000 ppm (high-Zn group), respectively. Diabetic recipient rats underwent islet transplantation, and the blood glucose levels and insulin secretion were monitored for 7 days after transplantation. RESULTS: The serum and pancreatic Zn levels at the time of donation were significantly lower in the low-Zn group (48.8 ± 25.5 μg/dL and 11.3 ± 1.9 μg/g) and higher in the high-Zn group (147.3 ± 17.6 μg/dL and 18.7 ± 2.2 μg/g) when compared with those observed in the controls (118.7 ± 7.9 μg/dL and 14.6 ± 2.0 μg/g) (P < 0.05). The blood glucose levels became re-elevated 2 days after transplantation in rats receiving islet grafts from the controls and the low-Zn groups. In contrast, in the rats that received islets from the high-Zn groups, these were maintained within a reference range (P < 0.01). CONCLUSIONS: These data indicate that a Zn-rich diet for donor rats improves the function of islet grafts in chemically induced diabetic rats. | |||||
書誌情報 |
Pancreas 巻 43, 号 2, p. 236-239, 発行日 2014-03 |
|||||
出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08853177 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MPA.0000000000000093 | |||||
権利 | ||||||
権利情報 | c 2014 by Lippincott Williams and Wilkins. | |||||
権利 | ||||||
権利情報 | This is a non-final version of an article published in final form in Pancreas, 43(2), pp.236-239; 2014 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pancreas, 43(2), pp.236-239; 2014 |