| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2015-04-01 |
| タイトル |
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タイトル |
Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats |
| 言語 |
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言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
dietary supplementation |
| キーワード |
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主題Scheme |
Other |
|
主題 |
graft function |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
islet transplantation |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
type 1 diabetes |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
zinc |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Mishima, Takehiro
Kuroki, Tamotsu
Tajima, Yoshitsugu
Adachi, Tomohiko
Hirabaru, Masataka
Tanaka, Takayuki
Kitasato, Amane
Takatsuki, Mitsuhisa
Eguchi, Susumu
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
OBJECTIVES: Zinc (Zn) is related to insulin synthesis, storage, and secretion. This study demonstrates the effects of Zn supplementation in donor rats on the outcomes of islet transplantation. METHODS: Donor rats received 3 different regimens of dietary Zn supplementation for 2 weeks before undergoing pancreas donation: a standard diet containing Zn at 50 ppm (control), 1 ppm (low-Zn group) or 1000 ppm (high-Zn group), respectively. Diabetic recipient rats underwent islet transplantation, and the blood glucose levels and insulin secretion were monitored for 7 days after transplantation. RESULTS: The serum and pancreatic Zn levels at the time of donation were significantly lower in the low-Zn group (48.8 ± 25.5 μg/dL and 11.3 ± 1.9 μg/g) and higher in the high-Zn group (147.3 ± 17.6 μg/dL and 18.7 ± 2.2 μg/g) when compared with those observed in the controls (118.7 ± 7.9 μg/dL and 14.6 ± 2.0 μg/g) (P < 0.05). The blood glucose levels became re-elevated 2 days after transplantation in rats receiving islet grafts from the controls and the low-Zn groups. In contrast, in the rats that received islets from the high-Zn groups, these were maintained within a reference range (P < 0.01). CONCLUSIONS: These data indicate that a Zn-rich diet for donor rats improves the function of islet grafts in chemically induced diabetic rats. |
| 書誌情報 |
Pancreas
巻 43,
号 2,
p. 236-239,
発行日 2014-03
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| 出版者 |
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出版者 |
Lippincott Williams and Wilkins |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
08853177 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1097/MPA.0000000000000093 |
| 権利 |
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権利情報 |
c 2014 by Lippincott Williams and Wilkins. |
| 権利 |
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|
権利情報 |
This is a non-final version of an article published in final form in Pancreas, 43(2), pp.236-239; 2014 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Pancreas, 43(2), pp.236-239; 2014 |
Pancreas43_236.pdf (284.3 kB)
