| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-09-01 |
| タイトル |
|
|
タイトル |
Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Genotype |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hemophilia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hepatitis C virus |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Human immunodeficiency virus |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Livercirrhosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Miuma, Satoshi
Hidaka, Masaaki
Takatsuki, Mitsuhisa
Natsuda, Koji
Soyama, Akihiko
Miyaaki, Hisamitsu
Kanda, Yasuko
Tamada, Yoko
Shibata, Hidetaka
Ozawa, Eisuke
Taura, Naota
Eguchi, Susumu
Nakao, Kazuhiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis. |
| 書誌情報 |
Experimental and Therapeutic Medicine
巻 15,
号 2,
p. 2148-2155,
発行日 2018-02
|
| 出版者 |
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|
出版者 |
Spandidos Publications |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17920981 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921015 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3892/etm.2017.5603 |
| 権利 |
|
|
権利情報 |
c 2018, Spandidos Publications. All rights reserved. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Experimental and Therapeutic Medicine, 15(2), pp.2148-2155; 2018 |
ETM15_2148.pdf (598.0 kB)
