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Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression
http://hdl.handle.net/10069/25146
http://hdl.handle.net/10069/251460d1bfc81-a976-4062-a301-04a8928a53c9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BioRes32_37.pdf (8.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-25 | |||||
| タイトル | ||||||
| タイトル | Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Goto, Hisataka
× Goto, Hisataka× Osaki, Makoto× Fukushima, Tatsuya× Sakamoto, Kazutaka× Hozumi, Akira× Baba, Hideo× Shindo, Hiroyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The TNF-family molecule, Receptor Activator of Nuclear factor κ B Ligand (RANKL) is known as a key regulator for bone remodeling, and is essential for the development and activation of osteoclasts. In this study, we examined the regulation of RANKL in primary human bone marrow adipocytes and the relationship between bone marrow adipocytes and bone metabolism. RANKL expression and the RANKL/osteoprotegerin (OPG) mRNA ratio in marrow adipocytes increased following dexamethasone treatment. In co-cultures of human osteoclast precursors and bone marrow adipocytes with dexamethasone, osteoclast precursors differentiated to TRAP-positive multi-nuclear cells. Moreover, the ability of bone resorption was confirmed in co-culture in flasks coated with calcium phosphate film. Osteoclast precursor differentiation and bone resorption were blocked by RANKL antibody pretreatment. TRAP-positive multinuclear cells did not form in co-culture without cell-to-cell contact conditions. We conclude that primary human bone marrow adi-pocytes have the ability to promote osteoclast differentiation and activities, similar to osteoblasts and other RANKL-expressing cells. | |||||
| 書誌情報 |
Biomedical Research 巻 32, 号 1, p. 37-44, 発行日 2011-02 |
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| 出版者 | ||||||
| 出版者 | Biomedical Research Foundation | |||||
| 出版者別言語 | ||||||
| 値 | バイオメディカルリサーチプレス | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03886107 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11126935 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2220/biomedres.32.37 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2011 Biomedical Research Press | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関係URI | ||||||
| 関連名称 | http://hdl.handle.net/10069/26698 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biomedical Research, 32(1), pp.37-44; 2011 | |||||
