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Tissue plasminogen activator enhances the hypoxia/reoxygenation-induced impairment of the blood-brain barrier in a primary culture of rat brain endothelial cells.
http://hdl.handle.net/10069/23082
http://hdl.handle.net/10069/23082dc01318b-188b-4402-b3c9-8f3d78472bd4
名前 / ファイル | ライセンス | アクション |
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CMN28_1139.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-24 | |||||
タイトル | ||||||
タイトル | Tissue plasminogen activator enhances the hypoxia/reoxygenation-induced impairment of the blood-brain barrier in a primary culture of rat brain endothelial cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blood-brain barrier | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain capillary endothelial cells (rat) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypoxia/reoxygenation (in vitro) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tight junction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tissue plasminogen activator | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transendothelial electrical resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transendothelial permeability | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hiu, Takeshi
× Hiu, Takeshi× Nakagawa, Sinsuke× Hayashi, Kentaro× Kitagawa, Naoki× Tsutsumi, Keisuke× Kawakubo, Junichi× Honda, Masaru× Suyama, Kazuhiko× Nagata, Izumi× Niwa, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hemorrhagic transformation is a major complication associated with tissue plasminogen activator (tPA) therapy for ischemic stroke. We studied the effect of tPA on the blood-brain barrier (BBB) function with our in vitro monolayer model generated using rat brain microvascular endothelial cells subjected either to normoxia or to hypoxia/reoxygenation (H/R) with or without the administration of tPA. The barrier function was evaluated by the transendothelial electrical resistance (TEER), the permeability of sodium fluorescein and Evans' blue-albumin (EBA), and the uptake of lucifer yellow (LY). The permeability of sodium fluorescein and EBA was used as an index of paracellular and transcellular transport, respectively. The administration of tPA increased the permeability of EBA and the uptake of LY under normoxia. It enhanced the increase in the permeability of both sodium fluorescein and EBA, the decrease in the TEER, and the disruption in the expression of ZO-1 under H/R conditions. Administration of tPA could cause an increase in the transcellular transport under normoxia, and both the transcellular and paracellular transport of the BBB under H/R conditions in vitro. Even in humans, tPA may lead to an opening of the BBB under non-ischemic conditions and have an additional effect on the ischemia-induced BBB disruption. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com | |||||
書誌情報 |
Cellular and molecular neurobiology 巻 28, 号 8, p. 1139-1146, 発行日 2008-12 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02724340 | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15736830 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10622352 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18629628 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10571-008-9294-x | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media, LLC 2008 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cellular and molecular neurobiology, 28(8), pp.1139-1146; 2008 |